Pauka Urolithin

Loaʻa iā Cofftek ka hiki i ka hana nui a me ka hoʻolako ʻana o urolithin a, urolithin b a me Methylurolithin A ma lalo o ke kūlana o cGMP.

He aha nā Urolithins?

ʻO nā Urolithins nā mea loaʻa a i ʻole nā ​​metabolites o nā ʻeleka acid acid e like me ellagitannins. Hoʻopili ʻia kēia mau mea kemika mai ellagic acid-derivatives e ka microbiota ʻōpū.

No ka mea nui ka flora ʻōpū no ka hana ʻana o nā urolithins, ʻo ka nui o nā urolithins i hana ʻia i loko o ke kino e pili ana i ke ʻano o nā meaola i loko o ka flora, ka meaola nui a ka hui leptum Clostridium. Ua hōʻike ʻia i ka poʻe me ka microbiota waiwai i nā lālā o kēia hui e hana i kahi helu kiʻekiʻe o nā urolithins ma mua o nā mea me nā flora ʻōpū e like me Bacteroides a Prevotella paha.

Hana ʻia nā Urolithins mai ka punicalagin i ka ʻōpū, e like me nā ellagitannins, a laila lawe ʻia i waho i ka mimi. No ka nānā ʻana i ka hana urolithin i loko o ke kino, pono e nānā i kā lākou pae i ka mimi o ke kanaka nāna i hoʻopau i nā meaʻai i waiwai i ka ellagic acid a i ʻole nā ​​mea hoʻohui me nā urolithins ma ke ʻano he kumu nui. ʻO Urolithin, i hoʻokahi manawa i ka plasma, hiki ke ʻike ʻia i ke ʻano o nā glucuronides.

Loaʻa kūlohelohe nā Urolithins i loko o nā meaʻai, ʻoiai ʻaʻole hiki ke lawe ʻia nā mole āpau o nā urolithins mai ka meaʻai. Ke hoʻokomo ʻia nā meaʻai i loko o ka waikawa ellagic, pili ia i ka flora ʻōpū e wāwahi i nā ellagitannins a me punicalagin i loko o nā metabolite waena a me nā huahana hopena; nā molekiola urolithin.

Ua loaʻa i kēia mau mole ke kaulana a hoʻomau i ka piʻi ʻana ma ke ʻano he suplemenia superfood ma muli o kā lākou anti-tumor, anti-age, anti-inflammatory, a me autophagy-inducing benefit. Eia kekahi, pili nā mole mole urolithin me nā pae ikehu i hoʻomaikaʻi ʻia no ka mea he hopena nui ia i ke olakino mitochondrial. ʻO ka hana ʻana i ka ikehu i ke kino kahi hana e kū i ka mitochondria, a me ka hoʻomaikaʻi ʻana i ka hana o kēia organelle kekahi o nā hana he nui a ka Urolithins.

Kaulana Molecules o Urolithin

Kuhi like nā Urolithins i nā mole ʻokoʻa e pili ana i ka ʻohana urolithin akā loaʻa nā ʻano kemika ʻokoʻa, nā inoa IUPAC, nā hanana kemika, a me nā kumuwaiwai. Eia kekahi, ʻokoʻa ʻokoʻa nā hoʻohana a me nā pōmaikaʻi o kēia mau mole i ke kino o ke kanaka a no laila hoʻolaha ʻokoʻa i ka palapala hoʻopihapiha.

ʻO Urolithins, ma hope o ka noiʻi nui ʻana, ʻike ʻia e haki i nā mole i loko o ke kino, ʻoiai ʻaʻole ʻike nui ʻia e pili ana i kēlā me kēia mole kikoʻī.

● Urolithin A (3,8-Dihydroxy Urolithin)
● Urolithin A glucuronide
● Urolithin B (3-Hydroxy Urolithin)
● Urolithin B glucuronide
● Urolithin D (3,4,8,9-Tetrahydroxy Urolithin)

ʻO Urolithin A a me Urolithin B, ʻoi aku ka ʻike ʻia ʻo UroA a me UroB, nā metabolite kaulana o Urolithins i ke kino. ʻO kēia mau mea ʻelua nā mole i hoʻohana ʻia i kēia manawa i nā mea hoʻopihapiha a me nā paina pani pāʻina.

I hoʻokahi manawa i ke koko, aia ʻo Urolithin A ma ke ʻano he Urolithin A glucuronide, a ʻo Urolithin B hiki ke ʻike ʻia ma ke ʻano he Urolithin B glucuronide. Ma muli o kēia, manaʻo ʻia he hopena like kā lākou e like me kā lākou mea i mua e like me ka hiki ʻole i nā noiʻi vivo me nā urolithins. ʻO ka nele o ka noiʻi vivo he mea paʻakikī e nānā inā loaʻa ka hopena o ka UroA a me ka UroB glucuronides mai UroA a me UroB iho.

ʻO Urolithin A kekahi kumu i hiki ke ʻike ʻia i ke koko, ʻo ia hoʻi, Urolithin A sulfate. Hana kēia mau derivatives āpau i kā lākou hana i ke koko a laila holoi ʻia i waho o ka ʻōnaehana ma o ka mimi.

ʻO Urolithin D kahi mole nui i hana ʻia e nā hopena o ka ʻōpū microbiota, akā naʻe, ʻaʻole nui ka ʻike e pili ana i nā hopena a me nā hoʻohana hiki. I kēia manawa, ʻaʻole hoʻohana ʻia ia i nā mea hoʻopihapiha a i ʻole nā ​​pānaina pāʻaina, ʻokoʻa i nā mea like, UroA a me UroB. Eia kekahi, ʻaʻole ʻike ʻia nā kumuwaiwaiʻai o Urolithin D.

ʻO Urolithin He ʻikepili ʻike he lepo

ʻAʻole loaʻa kūlohelohe ʻo Urolithin A mai nā kumu meaʻai a pili i ka hui o nā hui i ʻike ʻia ʻo benzo-coumarins a i ʻole dibenzo-α-pyrones. Hoʻolako maoli ʻia ia mai ellagitannins a i Urolithin A 8-Methyl Ether ma mua o ka wāwahi ʻia ʻana i Urolithin A. Loaʻa kēia huahana i ka nui ma kā mākou hale hana hana ma ke ʻano o ka pauka Urolithin A. Loaʻa ka MethylUrolithin A pau ka pauka e kūʻai i ka nui inā pono.

ʻAʻole loaʻa ʻo Urolithin A i nā pae like, ʻoiai me nā pae like o ka mea i mua o ia, i nā poʻe like ʻole no ka mea pili ia i ka hana o ka microbiota ʻōpū. Manaʻo ʻia ko ka metabolism a Urolithin A e koi aku iā Gordonibacter urolithinfaciens a me Gordonibacter pamelaeae akā hōʻike kekahi mau poʻe me kēia mau mea i ka liʻiliʻi o ka hopena i ka hana ʻana o ka mole.

ʻO Urolithin A he mau hiʻohiʻona kikoʻī e kū iā ia mai nā ʻaoʻao ʻē aʻe, e like me nā mea i ʻōlelo ʻia i ka papa ma lalo.

Kāleka CAS1143-70-0
Purity98%
Inoa IUPAC3,8-Dihydroxybenzo [c] chromen-6-hoʻokahi
'O Synonyms3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-one; 3,8-DIHYDRO DIBENZO- (B, D) PYRAN-6-ONE; 3, 8-Dihydroxy-6H-benzo [c] chromen-6-one; Puka Castoreum I; ʻO Urolithin A; 6H-Dibenzo (B, D) pyran-6-one, 3,8-dihydroxy-; 3,8-dihydroxy-6H-dibenzopyran-6-one); urolithin-A (UA; 3,8-dihydroxy-6H-dibenzo (b, d) pyran-6-one
Ka Lā MolecularC13H8O4
Molecular Weight228.2
Point Hoʻolālā> 300 ° C
InChI KeyRIUPLDUFZCXCHM-UHFFFAOYSA-N
anopaa
KeʻanoPauka melemele māmā
Ka Half-LifeʻAʻoleʻike
PalekanaHoʻopiliʻia i DMSO (3 mg / mL).
pūnaewele Kūlana:Nā lā i nā hebedoma: i kahi lumi pouli a me ka maloʻo ma 0 - 4 kekelē C Mahina i nā makahiki: i ka pahu hau, mai kahi wai ma -20 kekelē C.
noiHoʻohana ka meaʻai e like me ka meaʻai a me ka mea hoʻopili

ʻO ka ʻikepili ʻike hemo Urolithin B Powder

ʻO Urolithin B kahi hui phenolic i hoʻomaka wale e hana nui ʻia mai Ianuali o 2021. Hiki ke kiʻi ʻia e ka ʻai ʻana i nā meaʻai he mau kumuwaiwai kūlohelohe i hiki ke hoʻopili ʻia i loko o Urolithin B. Ua ʻike ʻia he mana anti-kūnewa hui pū i hiki iā ʻoe ke kūʻai i ka nui ma ke ʻano o ka pauka Urolithin B.

ʻO nā waiwai ʻokoʻa o ka pauma Urolithin B i loaʻa ma kā mākou ʻoihana hana i ʻōlelo ʻia ma lalo:

Kāleka CAS1139-83-9
Purity98%
Inoa IUPAC3-Hydroxy-6H-dibenzo [b, d] pyran-6-hoʻokahi
'O SynonymsAURORA 226; ʻO Urolithin B; AKOS BBS-00008028; 3-hydroxy urolithin; 3-hydroxy-6-benzo [c] chromenone; 3-hydroxybenzo [c] chromen-6-one; 3-Hydroxy-benzo [c] chromen-6-one; 3-HYDROXY-6H-DIBENZO [B, D] PYRAN-6-ONE; 6H-Dibenzo (b, d) pyran-6-one, 3-hydroxy-; 3-Hydroxy-6H-benzo [c] chromen-6-hoʻokahi AldrichCPR
Ka Lā MolecularC13H8O3
Molecular Weight212.2 g / mole
Point Hoʻolālā> 247 ° C
InChI KeyWXUQMTRHPNOXBV-UHFFFAOYSA-N
anopaa
KeʻanoʻŌpala kukui brown
Ka Half-LifeʻAʻoleʻike
PalekanaHiki ke hoʻoheheʻe ʻia ma 5mg / mL ke hoʻomehana ʻia, wai piha
pūnaewele Kūlana:2-8 ° C
noiPākuʻi anti-oxidant a me Pro-oxidant me ka hana estrogenic.


Ma waho o kēia mau mole nui o Urolithins i hoʻokumu ʻia ma ke ʻano he hopena o ka hana o ka flora gut, aia kekahi mau mole i waena i hana ʻia i ka wā o ka haki o nā mea mua. ʻO kēia mau waena waena:

● Urolithin M-5
● Urolithin M-6
● Urolithin M-7
● Urolithin C (3,8,9-Trihydroxy urolithin)
● Urolithin E (2,3,8,10-Tetrahydroxy urolithin)

ʻAʻole ʻike nui ʻia e pili ana i kēia mau waena waena e like me kēia manawa, eia nō naʻe, hiki i ka noiʻi hou ke ʻike i nā pōmaikaʻi a me nā hoʻohana o kēia mau mole o Urolithin.

Pehea e hana ai nā Urolithins?

ʻO nā Urolithins, e like me nā mea hoʻohui ʻē aʻe i hoʻohana ʻia i nā mea hoʻopihapiha, hoʻopili i nā ʻōnaehana like ʻole a me nā ʻōnaehana i ke kino, e hana i nā hopena maikaʻi. ʻO ke ʻano o ka hana o nā Urolithins, nā A a me ka B, hiki ke hoʻokaʻawale ʻia i ʻeono mau lālā nui, a he hiki i kēlā me kēia lālā ke hoʻohua i nā pono he nui.

● Nā Pono Antioxidant
ʻO ka pōmaikaʻi nui o ka loaʻa ʻana o nā waiwai antioxidant ka mea e hōʻemi ʻia ai ke koʻikoʻi oxidative i ke kino. ʻO ke koʻikoʻi oxidative pili i ke koʻikoʻi ma nā hunaola a me nā ʻaʻa i ke kino ma muli o nā hopena kemika e hana i nā hui paʻa ʻole, i ʻike ʻia hoʻi me nā radical free. Hiki i kēia mau radical manuahi ke komo hou i nā hopena kemika kūwili i loko o ke kino, nā huahana e hōʻino ai i nā hunaola a me nā aʻa.

Hoʻopau nā Urolithins i kēia stress oxidative, nā hopena i ka pāpā ʻana i ka ʻeha a hoʻonui i nā manawa o ke ola cell. ʻO kēia mau hopena i hiki ke hana ʻia ma o ka hōʻemi ʻia ʻana o ka hana o intracellular Reactive Oxygen Species (iROS), kahi ʻano o nā radical manuahi. Eia kekahi, ʻo nā waiwai antioxidant o Urolithin A a me Urolithin B e ala aʻe hoʻi ma o ka hoʻemi ʻia o ka NADPH oxidase subunit expression, he mea nui ia no nā hopena kemika i hopena i ka stress oxidative.

E hana i nā waiwai antioxidant, Hoʻonui pū ka Urolithins i ka hōʻike o antioxidant heme oxygenase-1 ma o ke ala hōʻailona Nrf2 / ARE. Kōkua kēia iā lākou ʻaʻole e hoʻoliʻiliʻi wale i nā pūhui hōʻino akā e hoʻonui pū i nā enzyme maikaʻi e hāpai i nā waiwai antioxidant.

ʻO Urolithins, ke hāʻawi ʻia i nā ʻiole me ka ʻino o ka lolo i hoʻokomo ʻia e LPS, ua kāohi i ka hoʻoulu ʻana o microglial, a i ʻole ma nā ʻōlelo maʻalahi, nā ʻili a me nā mumū e hoʻonui ai i ka hopena o ka lolo kū mau. Kuhi ʻia kēia hopena o nā urolithins i ka hoʻohui o nā waiwai antioxidant a me nā anti-inflammatory waiwai.

● Nā Kūʻai Kūʻai Kūʻai Anti
ʻO nā waiwai anti-inflammatory o Urolithins kekahi o nā kumu nui no ka piʻi ʻana o ka kaulana i ka honua kōpiko. ʻO ke ʻano a me kēia mau hui, ʻo ia hoʻi ʻo Urolithin A, Urolithin B, a me kā lākou mau glucuronides, ʻokoʻa ākea a hua like nā hopena.

ʻO ka hopena anti-inflammatory o Urolithin A a me Urolithin B he ʻano like me ka Non-Steroidal Anti-inflammatory Drugs a i ʻole NSAID e like me Ibuprofen a me Aspirin. ʻIke ʻia nā hopena o ka Urolithins i ka hana o PGE2 a me ka hōʻike o COX-2. Ke kāohi nei ʻo NSAID i ka hōʻike o ka COX 1 a me ka COX 2, hiki ke hoʻoholo ʻia he mana koho anti-inflammatory hou kā ka Urolithins.

Ua hōʻoia ʻia nā ʻano anti-inflammatory o Urolithins ʻaʻole wale e hakakā i ka hoʻowahāwahā i ke kino akā hiki nō hoʻi iā lākou ke hoʻohuli i ka poino i hana ʻia i nā ʻokena ma muli o ka hoʻowahāwahā lōʻihi ʻana i hopena ai ka maikaʻi ʻole o ke kino. I loko o kahi noi i hana ʻia e pili ana i nā hiʻohiʻona holoholona, ​​ua ʻike ʻia ka hiki i ka hoʻohana ʻana i ka urolithin ke hoʻopololei i ka nephrotoxicity i hoʻowalewale ʻia e ka lāʻau ma ke kāohi ʻana i ka make a me ka mumū o ka pūpū.

Ua loaʻa ia urolithin A pauka, hāʻawi waha ʻia, i kahi hopena kaohi ma ke ala uila me ka proapoptotic cascade, no laila, pale i ka hana renal. ʻO kēia mau waiwai o Urolithin A a me nā wahi urolithins ʻē aʻe i kahi wā e hiki mai ana kahi hiki ke hoʻohana ʻia i kēia mau mea hoʻohui lāʻau me kā lākou hoʻohana i kēia manawa ma ke ʻano he mea hoʻohui.

● Nā Waiwai anti-Carcinogenic
Manaʻo ʻia ʻo Urolithins he anti-carcinogenic ma muli o ko lākou hiki ke loaʻa nā hopena e like me ka hopu ʻana o ka uila, ka pāpā ʻana i ka aromatase, ka hoʻokomo ʻana i ka apoptosis, ka pehi ʻana i ka tumo, ka paipai ʻana i ka autophagy, a me ka senescence, ka hoʻoponopono transcriptional o oncogenes, a me nā mea loaʻa nā mea ulu. ʻO kēia mau hopena, inā ʻaʻole, hiki i ka ulu aberrant o nā hunaola maʻi ʻaʻai. Ua hōʻoia ʻia nā hiʻohiʻona Preventive o Urolithins, keu hoʻi no ka maʻi ʻaʻai prostate a me ka maʻi ʻaʻai kolone, me nā mea noiʻi he nui e ʻākoakoa ana no ka hoʻohana ʻana o Urolithins i mea hiki ke pale ʻia no ka maʻi ʻaʻai prostate.

Ua hoʻopaʻa ʻia kahi noiʻi i hana ʻia ma ka makahiki 2018 i nā hopena o Urolithin ma ke ala mTOR me ka manaʻo e loaʻa i kahi koho lapaʻau no ka maʻi ʻaʻai pancreatic. Pili ka maʻi ʻaʻai Pancreatic me nā helu make kiʻekiʻe, akā hōʻike ʻia nā noiʻi hou e hiki i ka Urolithin ke hoʻonui wale i ka helu ola akā ke kāohi nei hoʻi i ka hoʻopili ʻana i nā hunaola tumora i nā ʻāpana ʻē aʻe o ke kino, a laila hopena ka metastasis. Ua aʻo pono ʻia ʻo Urolithin A a ua hoʻohālikelike ʻia nā hopena i nā hopena i hana ʻia e ka regimen maʻamau maʻamau. Ua hoʻoholo ʻia ua hana ʻo Urolithin A i nā hopena maikaʻi ke hoʻohana ʻia e mālama i ka maʻi ʻaʻai pancreatic, i nā kūlana ʻelua. ke hoʻohana wale ʻia a i ʻole me ka hoʻolālā lapaʻau maʻamau.

Me ka noiʻi hou aʻe, loaʻa i nā pono Urothilins i ka mālama ʻana i ka maʻi ʻaʻai pancreatic pū kekahi.

● Nā Pono Antibacterial
ʻIke ʻia nā Urolithins no kā lākou waiwai antibacterial a loaʻa kēia hopena iā lākou ma ke kāpae ʻana i nā kaha kamaʻilio o nā microorganism, ʻaʻole e ʻae iā lākou e neʻe a pili ʻole i nā hunaola. Manaʻo ʻia he waiwai antifungal lākou, ʻoiai ʻaʻole maopopo ka ʻōnaehana kikoʻī.

Aia he ʻelua mau pathogens i loaʻa i nā Urolithins ka hopena pāpā ikaika ikaika i ka hopena o ka pale no ke kino o ke kanaka. ʻO kēia mau pathogens he microbe malarial a me Yersinia enterocolitica, me nā mea ʻelua e hoʻoulu ai i nā maʻi ʻino i nā kānaka. ʻO ke ʻano e loaʻa ai i nā Urolithins nā waiwai antibacterial me ka nānā ʻole i ka meaola.

● Nā Waiwai anti Estrogenic a me Estrogenic
ʻO ka Estrogen kahi hormone nui i loko o ke kino wahine, a ʻo ka hāʻule o kāna mau pae e pili pū ʻia me nā ʻōuli e like me ka flushing, nā wela wela, a me ka hōʻemi ʻana i ka nui o ka iwi. Hāʻawi ʻia i ke koʻikoʻi o ka hōmona, he mea kūpono ke ʻimi ʻimi ʻia kahi mea pani. Eia nō naʻe, he mau hopena ʻē aʻe nā hormones exogenous e hoʻohana pono ʻole ʻia ai kā lākou hoʻohana ʻana.

Eia nō naʻe, like ke ʻano o Urolithin A a me Urolithin B me ka estrogen like endogenous a me kahi pilina no nā mea loaʻa nā estrogen i ke kino. He ʻoi aku ka ikaika o ka pilina o Urolithin A, keu hoʻi no ka receptor alpha i hoʻohālikelike ʻia me ka receptor beta. ʻOiai ʻelua o kēia mau pūhui i ka like o ke ʻano me ka estrogen, ʻo nā urolithins he ʻelua estrogen a me anti-estrogenic waiwai, ʻokoʻa ka estrogen hopena.

ʻO ke kaulike o kēia hopena o Urolithins e hoʻolilo iā lākou i koho koho kūpono no kekahi mau maʻi e kū aʻe ke hāʻawi ʻia ka estrogen exogenous e mālama i nā hōʻailona o ka hemahema estrogen.

● Pākuʻi Glycation Protein
ʻO ke protein glycation kahi hana e paʻa ai kahi mole kō i kahi protein. ʻIke ʻia kēia hana i ka wā ʻelemakule a i ʻole he mahele o kekahi mau maʻi. Hoʻopau ka Urolithins i ka hoʻohui o ke kō, no laila e hoʻoulu nei i nā hopena anti-glycation. Eia kekahi, ke kāohi nei lākou i ka endlyproductions glycation holomua, ka hōʻiliʻili ʻana o ia mea he pae pathophysiological koʻikoʻi i ka ulu ʻana o ka maʻi kō.

Nā pono o nā Urolithins

He ʻokoʻa nā ʻano hana o ka Urolithins e hana i nā kōkua pale ʻokoʻa i ke kino o ke kanaka. ʻO Urolithin A paukū a me Urolithin B pauma e kōkua i ka hana ʻana i nā mea hoʻopiha i kaulana no ka maikaʻi o nā mea nui. Kākoʻo ʻia nā pōmaikaʻi āpau o kēia mau hui kemika e nā ʻike ʻepekema, a ke hana ʻia nei kahi noiʻi hou e kākoʻo i ka hoʻohui o Urolithins i nā alakaʻi no ka mālama ʻana i kekahi mau maʻi.

ʻO nā pōmaikaʻi o kēia mau mea hoʻohui, e pili ana i nā ʻano hana i ʻōlelo ʻia i luna, me:

● Nā Pono Antioxidant
Lawe ʻia ʻo Urolithins mai kekahi mau meaʻai momona ellagitannins i ʻike ʻia e waiwai nui i nā antioxidants. ʻO ke kumuwaiwai meaʻai maʻamau no ellagitannins a me el acid acid he pomegranates, a he kumu waiwai nui kekahi no nā antioxidants. Eia nō naʻe, he mea nui e hoʻokaʻawale inā pili like nā waiwai antioxidant o ke kumu meaʻai a me nā urolithins a i ʻole inā kiʻekiʻe aʻe ka kiʻekiʻe o kekahi ma mua o kekahi.

Ua hōʻike ʻia nā noiʻi mua o Urolithin A a me Urolithin B he 42 mau manawa ka liʻiliʻi o nā hopena antioxidant o kēia mau mea ma mua o nā hua ponoʻī, no laila e hōʻike nei ʻaʻole e hana kēia mau mea hoʻohui kemika i nā mea pono maikaʻi no nā mea hoʻopiha.

Eia nō naʻe, ʻo nā noiʻi hou me kahi ʻano ʻokoʻa o ke kālailai e hōʻike nei he maikaʻi loa ʻo Urolithin A a me B a he mau mana antioxidant ikaika e hakakā ai i nā hopena o ke kaumaha oxidative. I ka hoʻohana ʻia ʻana o ke ʻano like o ke kālailai ʻana e hoʻopaʻa i nā urolithins āpau e ʻike ʻo wai ka mea mana loa, kū i waho ʻo Urolithin A. A laila ua kope ʻia nā hopena i kahi noiʻi like me Urolithin A e alakaʻi nei i ka ikaika, hou.

I ka ʻoiaʻiʻo, ua nānā kekahi o nā noiʻi i ka loiloi ʻana i nā waiwai antioxidant o kēia mau mea hoʻohui kemika ma o ka hoʻāʻo ʻana i ko lākou hiki ke hakakā i ke koʻikoʻi oxidative. No ke kumu o kēia noi ʻana, ua hoʻokomo nā kānaka noiʻi i ke koʻikoʻi i nā hunaola neuronal a ke hōʻike ʻia i nā Urolithins, ʻo ia hoʻi ʻo Urolithin B, ua ʻike lākou i ka hoʻoliʻiliʻi loa o ke koʻikoʻi a me ka hoʻonui ʻana i ka hiki ke ola o nā ʻola neuronal.

● Nā Kūʻai Kūʻai Kūʻai Anti
ʻO nā waiwai anti-inflammatory o Urolithins e hana i nā pōmaikaʻi he nui, a ʻo nā mea āpau i hōʻoia ʻepekema ʻia.

1.Antimalarial hopena
ʻO kahi lāʻau homeemade no ka mālama malaria e hoʻohana ākea ʻia ma kekahi mau wahi kaiāulu e pili ana i ka hoʻohana ʻana o ka Pomegranate. Ua hoʻāʻo ka poʻe noiʻi e hoʻomaopopo i ka hopena maikaʻi o kēia lāʻau i ka mālama ʻana i ka malaria e ka hoʻopili ʻana i nā hopena me nā hopena o Urolithins i hana ʻia i ka ʻōpū mai ka pomegranate.

Ua mālama ʻia kahi noiʻi e hoʻopaʻa i ka hopena o ka Urolithins i ka mālama ʻana i ka malaria e ka hōʻike ʻana i nā hunaola monocytic i loaʻa i nā Urolithins. Ua ʻike kēia noiʻi i nā mea hoʻohui kemika e kāohi i ka hoʻokuʻu o MMP-9, kahi metalloproteinase koʻikoʻi i ka hoʻomohala ʻana a me ka pathogenesis o ka malaria. ʻO ka pāpā ʻana i ka mea hoʻohui e kāpae i ka malaria mai ka pathogenic i loko o ke kino, no laila ke kumu e manaʻo ʻia ai he hopena antimalarial.

Ua hōʻike pū ʻia nā hopena o ke aʻo ʻana ua kāohi nā Urolithins i ka ʻōlelo mRNA o nā pathogens malarial, a laila ua kāohi hou ʻia ka hiki i nā microorganism ke hana i ka maʻi. Hōʻike nā hopena o kēia noi i nā hopena maikaʻi o nā lāʻau āpau e like me ka pomegranate ma muli o nā hopena o urolithin.

2. Ka hopena ma nā Kelepona Endothelial
ʻO Atherosclerosis kahi kūlana maʻamau e alakaʻi i nā hōʻino cardiac a me nā infoction myocardial. ʻO nā kumu maʻamau ʻelua ma hope o ka hoʻomohala atherosclerosis ka hopena endothelial a me ka mumū. Ua hoʻāʻo nā noiʻi hou e hōʻoia i ka anti-inflammatory waiwai o Urolithin i hiki ke pale i ka hana ʻole endothelial, a no laila, mālama i ka hoʻokumu atherosclerosis a me ka hoʻomohala.

Ua loaʻa ʻo Urolithin A e nā kānaka noiʻi e loaʻa ka hana anti-inflammatory kiʻekiʻe loa ma waena o nā urolithins āpau. ʻO kahi noiʻi hou e pili ana i nā pūnaewele endothelial kanaka i hoʻopili ʻia me ka LDL oxidized, kahi mea e pono ai no ka hoʻokumu atherosclerosis, a me nā ʻano like ʻole o Urolithin A. Ua ʻike nā kānaka noiʻi ua kāohi ʻo Urolithin A i ka synthase nitric oxide a hoʻemi i ka ʻōlelo o I-CAM, a ʻo ia ka hopena. hoʻemi i ka mumū a hoʻemi i ka hiki o nā hunaola, ʻo ia hoʻi nā monocytes e pili pono i nā hunaola endothelial. Hoʻoemi ka mālama monosittic i ka hopena endothelial.

Eia kekahi, ua loaʻa ʻo Urolithin A e hoʻēmi i ka ʻōlelo o ka tumrosis factor α, interleukin 6, a me ka endothelin 1; nā cytokine pro-inflammatory āpau.

3. Ka hopena ma Fibroblasts ma ke kolona
Hōʻike ʻia ʻo Colon i nā pathogens exogenous a me nā mea ʻai e hoʻoweliweli ai i ka pehu, a i ka wā lōʻihi e hiki ai i nā pilikia olakino. ʻOiai ʻo Urolithin A a me Urolithin B e hana ʻia e ka flora ʻōpū, he mea nui e ʻike i ko lākou hopena i ka mua ma ke kino a lākou i hana ai.

No ke aʻo ʻana i nā hopena o Urolithins ma nā hunaola kolone a me nā fibroblast, ua hana kahi mea noiʻi i kahi hoʻokolohua kahi i hōʻike ʻia ai nā fibroblast i nā cytokine pro-inflammatory a laila iā Urolithins. E like me ka mea i ʻōlelo ʻia ma luna, ua ʻike ʻia ka pāpā ʻana o Urolithins i ka hoʻopili ʻana o ka monocyte a me ka neʻe ʻana o fibroblast e kāohi i ka mumū ma ke kolona.

Eia kekahi, ua ʻike ʻia ua kāohi ʻo Urolithins i ka hoʻoulu ʻana o ka mea NF-κB, a he mea nui ia no ka hoʻoponopono ʻana o ka mumū. ʻO ka ʻoiaʻiʻo, manaʻo ka poʻe noiʻi ʻo kēia ke kumu nui ma hope o nā anti-inflammatory waiwai o urolithins.

● Nā Waiwai anti-Carcinogenic
Pili nā Urolithins me nā waiwai anti-cancer, a ʻo ke ʻano o kēia mau waiwai i ʻōlelo ʻia ma luna. Eia naʻe, ʻo nā pōmaikaʻi o kēia mau waiwai i ʻōlelo ʻia ma lalo:

1. Ka palekana mai ka maʻi ʻaʻai Prostate
Hana pinepine ʻia ka ʻike ʻana o nā Urolithins i ke kino ma ka hoʻohana ʻana i ke koko a i ʻole ka mimi; Eia naʻe, hiki ke ʻike ʻia lākou i ke kolona o nā kāne a me nā wahine a me ka gland prostate o nā kāne.

Ma ke ʻano he hopena o kēia loaʻa ʻana, ua hoʻāʻo ka poʻe noiʻi e nānā inā ʻike ʻia nā pōmaikaʻi o nā hui kemika i loko o ka gland prostate e like me lākou i loko o ke kolona. No laila, ua hoʻolālā ʻia kahi noiʻi, a ʻo nā hopena i hōʻike ʻia he mana pale ko ka Urolithins ma ka gland prostate.

ʻIke ʻia ʻo Urolithin A a me Urolithin B, me Urolithin C a me Urolithin D i kāohi i ka CYP1B1 enzyme i loko o ka gland prostate. ʻO kēia enzyme ka pahuhopu o chemotherapy a ua kāohi ikaika ʻia e Urolithin A, hoʻohālikelike ʻia me nā urolithins ʻē aʻe. Ua kāohi lākou iā CYP1A1, akā naʻe, koi ʻia kahi kiʻekiʻe o nā urolithins e hana i kēlā hopena.

Ua mālama ʻia kahi noiʻi ʻē aʻe e hoʻopaʻa i nā hopena pale prostate o Urolithins. Ua ʻike ʻia he hopena anti-cancer ʻo Urolithin A i ka maʻi ʻaʻai prostate ma o nā ʻano ʻelua, p53 kaukaʻi a me p53 kūʻokoʻa kūʻokoʻa.

2. Kaohi ʻana o Topoisomerase 2 a me CK 2
Loaʻa nā Urolithins i nā waiwai anti-cancer ma o ka pāpā ʻana o kekahi mau ala mole i hopena pololei a i ʻole ʻole i ka hopena o ka ulu ʻana o ka maʻi ʻaʻai. ʻO ka enzyme CK2 kahi mea nui nui i komo i loko o ia mau ala mole molaki, me kāna hana nui e hoʻoliʻiliʻi i ka mumū a me ka maʻi ʻaʻai.

Hoʻopili nā Urolithins i nā ala like ʻole e kiʻi i ka enzyme ubiquitous, CK2 e kāohi i ka hopena, e like me nā mea e hoʻolaha ana i ka maʻi ʻaʻai. Ua hōʻike ʻia ʻo Urolithin A i mea kāohi iā CK2 ikaika, i ka silico.

Pēlā nō, manaʻoʻiʻo ʻia ka pāpā ʻo Topoisomerase 2 he hopena anti-cancer. I ka ʻoiaʻiʻo, hoʻohana ʻia kēia ʻano hana e kekahi mau chemotherapy e like me Doxorubicin. I loko o kahi noiʻi hou, ua ʻike ʻia ʻo Urolithin A ʻoi aku ka ikaika ma mua o Doxorubicin i ka pāpā ʻana iā Topoisomerase 2, no laila ke kāhea nei no ka hoʻohui ʻana i nā alakaʻi o kēia manawa no ka mālama ʻana i kekahi mau maʻi maʻi maʻi.

● Nā Pono Antibacterial
ʻO nā waiwai antibacterial o Urolithins kaukaʻi ʻia i ka pāpā ʻo Sensing Inhibition e lawe i ka hiki o ka microorganism e kamaʻilio, neʻe, a hana i nā mea virulence. He ʻano nui ia no ke ola ʻana o nā koʻohune, a ʻo kona pāpā ʻana e Urolithins he mea make ia no ka microorganism.

ʻO ka waiwai antibacterial nui o Urolithin ka hiki ke pale i ka ʻōpū mai ka ulu nui o Yersinia enterocolitica. ʻO ka ʻoiaʻiʻo, pili pū nā Urolithins me ka modulate o ka flora ʻōpū, ʻo ka flora like ke kuleana no kā lākou hana i ka mua. He mea nui loa kēia ma muli o nā meaola kikoʻī wale nō i ka flora hiki ke hoʻonui i ka hana o Urolithins.

● Nā Waiwai anti Estrogenic a me Estrogenic
Hoʻopili nā Urolithins i nā mea loaʻa iā Estrogen a hana i nā mea ʻelua, estrogen a me anti-estrogenic. ʻO kēia ka mea i moho nui no Selective Estrogen Receptor Modulator a i ʻole SERMs, ke ʻano nui o ka hopena e loaʻa ka hopena maikaʻi i hoʻokahi wahi o ke kino a me kahi hopena kaohi ma nā wahi ʻē aʻe o ke kino.

I hoʻokahi o nā noiʻi i hana ʻia i nā hopena o nā urolithins ma nā estrogen receptor, ua ʻike ʻia ʻo lākou, ʻo ka urolithin A hoʻi, ke kāohi nei i ka hōʻike o ka gen-endometrial cancer cells, a ʻo ia ka hopena o ke kanikau endometrial. ʻO ka endometrial hypertrophy kahi hopena maʻamau o ka estrogen exogenous i ka neoplasia post e like me nā wahine e lawe ana i ka hormone replacement therapy, a manaʻo ʻia ka hoʻohana ʻana o nā urolithins i kahi hopena pale i ka endometrium. Eia nō naʻe, pono e hana hou i kahi noiʻi hou ma mua o ka lilo ʻana o Urolithins i lāʻau lapaʻau SERM aʻe.

● Pākuʻi Glycation Protein
ʻO ke kū ʻana o nā huahana glycation hopena kiʻekiʻe kahi hiʻohiʻona o hyperglycemia e predisposes ka poʻe i ka maʻi maʻi maʻi e pili ana i ka maʻi diabetes a i ʻole ka maʻi ʻo Alzheimer. Ua hōʻike ʻia ʻo Urolithin A a me Urolithin B i kahi hopena anti-glycation e pale ai i nā hōʻino ʻana o ka naʻau a hoʻemi i ka makaʻi o ka neurodegeneration me ka nui.

No laila, ʻo ka pāpā ʻana o ka glycation protein e Urolithins i manaʻo ʻia he ʻelua nā hopena cardioprotective a me nā neuroprotective.

ʻO nā pono o Urolithin A kikoʻī i ʻōlelo ʻia ma lalo:

● Hoʻonui i ke ola
Hiki i ka ʻelemakule, ke koʻikoʻi, a me kekahi mau maʻi ke hōʻino i ka mitochondria, he mea nui ia no ka hana ʻana o ka ikehu maʻamau a hoʻohana i ke kino. Eia kekahi, kapa pinepine ʻia ka mitochondria ma ke ʻano he "powerhouse of the cell", kahi e hōʻike ai i kona koʻikoʻi no ka hana maʻamau o ka cell. No laila, ʻo kekahi mea i hōʻino ʻia i kēia hale mana e hopena maikaʻi ʻole i ka pūnaewele a hoʻoliʻiliʻi nui i kona ola.

Hoʻokomo nā Urolithins i kahi hopena kikoʻī i kapa ʻia ʻo mitophagy e ʻae ai i ke kino e hemo i ka mitochondria i hōʻino ʻia, me ka nānā ʻole i ke kumu o ka hōʻino, a hoʻonui i ka lōʻihi o ke ola. Ma muli o ka nui o ka pōʻino, hiki ke hana hou ʻia ka mitochondria no nā mea momona a me ka hana ʻana i ka ikehu.

● Neuroprotective
E like me ka mea i ʻōlelo ʻia ma luna nei, he waiwai anti-inflammatory kā ka urolithins a ʻo kēia mau waiwai e hāpai i ka hoʻokumu ʻana o ka cell neuronal i ka lolo, kahi hopena maikaʻi i ka noʻonoʻo a me ka paʻa ʻana o ka hoʻomanaʻo. Eia kekahi, pale aku ʻo Urolithin A i ka neurodegeneration i ʻike ʻia me ka maʻi ʻo Alzheimer, no laila, nā hopena neuroprotective.

● Kāohi i ka maʻi ʻaʻai Prostate
He waiwai anti-cancer ʻo Urolithin A akā ʻike maka ʻia ia i ka hihia o ka maʻi ʻaʻai prostate, me nā noiʻi e hāpai ana i ka hoʻohana ʻana i ka pomegranate a me nā kumuwaiwai ʻē aʻe o Urolithins no ka mālama ʻana i ka maʻi ʻaʻai Prostate.

● E mālama i ka momona
He hopena anti-obesity ʻo Urolithin A no ka mea ʻaʻole ia e kaohi wale i ka hōʻiliʻili ʻana o nā momona momona i ke kino akā pale pū kekahi i nā māka i kuleana no ka adipogenesis. I kahi noiʻi i hana ʻia i nā hiʻohiʻona holoholona, ​​ua ʻike ʻia he hopena kiʻekiʻe ko Urolithin A ma ka T3 thyroid hormone, kahi e hoʻonui ai i ka lilo o ka ikehu i nāʻiole. Hoʻokomo kēia i ka thermogenesis a hoʻoheheʻe i ka momona momona, ʻoiai ke hoʻokomo ʻia nei ka momona keʻokeʻo i loko o ka browning.

I ke ʻano like o ka noiʻi, ua ʻike ʻia he hopena ka URolithin A i ka momona a hiki i nāʻiole i hānai ʻia i kahi papa momona momona. Hōʻike kēia i nā hoʻohiki nui e pili ana i ka momona a ua kāhea nā mea noiʻi i nā noi kanaka o kēia mau hopena i hiki ke hoʻohana i kēia hui e hakakā i ka maʻi ahulau momona.

ʻO nā keu pono o Urolithin B ma lalo:

● Kāohi i ka nalo ʻana o nā mākala
Mahele ʻo Urolithin B i kekahi o nā pono o Urolithin A akā he hoʻokahi pono kūpono ia, kū hoʻokahi iā ia iho. ʻIke ʻia ʻo Urolithin B e pale i ka nalo ʻana o nā mākala ma nā kūlana physiological a me nā pathological. Eia kekahi, paipai ia i ka ulu ʻana o ka ʻiwi iwi ma ka hoʻonui ʻana i ka synthesive protein i nā mākala.

Loaʻa iā ia kahi hopena pale i ka atrophy muscle e like me ka mea i ʻike ʻia i kahi noiʻi i hana ʻia ma nāʻiole i ʻoki ʻia ko lākou aʻa sciatic. ʻO kēia ke alakaʻi i ka atrophy muscle akā ua hoʻokomo ʻia nāʻiole me nā pauma osmotic liʻiliʻi i hāʻawi mau iā lākou iā Urolithin B. ʻIke ʻia ua hoʻopaʻa ʻia kēia mauʻiole i kā lākou ala ubiquitin-proteasome, a ua alakaʻi ʻia i ka hemahema o ka atrophy muscle ma muli o ka sciatic nerve sectionation. .

Nā hana o Urolithins

Loaʻa nā Urolithins mai nā hui kūlohelohe a manaʻo ʻia kā lākou mau mea hoʻopihapiha e hoʻomanawanui maikaʻi ʻia me ka mea hōʻike ʻole ʻona. Eia nō naʻe, mea nui e hoʻomanaʻo i kēia mau pūhui ke waiho ʻia nei ma lalo o ka noiʻi a loaʻa nā palena o nā ana e pono e mālama pono ʻia.

● Urolithin A
Ma hope o ka noiʻi ākea e pili ana i nā pono o Urolithin A, ua hana ʻia kekahi mau noiʻi noiʻi e loiloi i ke ana pono o kēia hui kemika. ʻO ka absorption, Dig digest, Metabolism, a me ka hoʻopau hoʻopau ʻana i hana ʻia e kālailai i nā hiʻohiʻona o ka hui.

Ua mahele ʻia ke aʻo ʻana i ʻelua, kaukaʻi ʻia i ka helu o nā lā, a ua ʻike ʻia ka hoʻopaʻa ʻia ʻana o 28 mau lā me 0, 0.175, 1.75, a me 5.0% o Urolithin A i hui pū ʻia me ka papaʻai a me nā lā 90 me ka 0, 1.25, 2.5, a me 5.0% Urolithin A i hui pū ʻia me ka papa ʻaina ʻaʻole hōʻike i nā loli i nā palena maʻi, kemika o ke koko, a i ʻole hematology, a ʻaʻole ia i hōʻike i kekahi ʻano lāʻau ʻona kikoʻī. ʻO nā haʻawina ʻelua i loaʻa ka lāʻau kiʻekiʻena i hoʻāʻo ʻia ma 5% UA ma ke kaupaona ʻana i ka papaʻai i alakaʻi ʻia ai i nā lā aʻe; 3451 mg / kg BW / lā i nā kāne a me 3826 mg / kg BW / lā i nā wahine i ke aʻo waha ʻana he 90 mau lā.

● ʻO Urolithin B
E like me Urolithin A, ua aʻo nui ʻia ʻo Urolithin B e loiloi i ke ana pono. ʻOiai he mea nui e hoʻomaopopo i ka nānā ʻana o nā noiʻi i ka lāʻau palekana e loaʻa ai ka hoʻonui ʻia o nā mākala maikaʻi loa. Ua ʻike ʻia kēia mahele lāʻau he 15uM, no nā kāne ʻelua, me ka nānā ʻole i ke kaumaha.

● ʻO Urolithin A 8-Methyl Ether
Hoʻohana ʻia kēia hui pū, no ka mea he waena waena ia i ka wā o Urolithin A hana. Eia naʻe, ʻaʻole lawa ka noiʻi ʻana i hana ʻia no kahi hana kūpono e hoʻoholo ʻia no kēia Urolithin kikoʻī.

Nā Punawai Meaʻai o Urolithins

ʻAʻole i loaʻa kūlohelohe nā Urolithins i nā kumu meaʻai, akā naʻe, ʻike ʻia lākou he ellagitannins. ʻO kēia mau tannins e wāwahi i loko o ka ellagic acid, kahi e hoʻopili hou i loko o Urolithin A 8-Methyl ether, a laila i Urolithin A, a ʻo ka hope loa, ʻo Urolithin B. ʻO nā meaʻai e waiwai i nā Urolithins:

KumuʻaiʻAikika Ellagic
Nā hua (mg / 100g hou kaumaha)
ʻEleau150
ʻO nā raspberry ʻeleʻele90
ʻO Boysenberry70
Kapua315.1
pomeraite> 269.9
Kūpopo270
Puʻupuʻu Rose109.6
Strawberries77.6
Jam Strawberry24.5
ʻO nā raspberry melemele1900
Nuts (mg / g)
Pecans33
ʻO Walnuts59
Mea inu (mg / L)
ʻO ka wai momona811.1
ʻO Cognac31-55
Waina ʻulaʻula makahiki ʻelemakule33
lama1.2
Nā hua (mg / g)
ʻO nā raspberry ʻeleʻele6.7
Nā raspberry ʻulaʻula8.7
ʻO Boysenberry30
Mango1.2


E like me ka mea i ʻike ʻia i ka papa, ʻo Cloudberry nā hua me ka Ellagitannins kiʻekiʻe a me ka waikawa Ellagic, me ka Pomegranate ma ke kekona kokoke. ʻO ka wai Pomegranate, he kumu ʻoi aku ka mana, kokoke i ʻekolu mau manawa e like me ka ikaika me Cloudberry.

He mea nui e hoʻomaopopo i ka ʻike o ka acid ellagic i loko o nā kumuwaiwai ʻai ʻaʻole like ia me ka nui o ka urolithin i loko o ke kino. ʻO ka bioavailability o nā URolithins hilinaʻi nui i ka ʻōpū microbiota o kēlā me kēia.

No ke aha ʻoe e kūʻai ai mai kā mākou hale hana hana hana?

Loaʻa ka Urolithin Powder A a me Urolithin Powder B i ka nui, ma kā mākou hale hana hana e hoʻopili i ka hana, noiʻi, hoʻomohala, a me ke kūʻai aku ʻana o ia mau mea hoʻohui. Hana ʻia kā mākou huahana me ka hoʻohana ʻana i ke kikoʻī loa e hāhai i nā kulekele palekana āpau, kahi e hōʻoia ai i ke kiʻekiʻe kiʻekiʻe a me ka palekana o ka huahana hope loa. ʻImi ʻia nā huahana āpau ma mua o ka hana ʻana a hoʻāʻo maikaʻi ʻia i ka wā a ma hope o ka hana ʻana e hālāwai me kāu mau kūlana maikaʻi.

Ma hope o ka hana ʻana, hoʻāʻo ʻia nā huahana ma kā mākou hale hana i hoʻokahi manawa hou e nānā ai no ka maikaʻi, ikaika, a me ka palekana o nā paukū Urolithin a me nā huahana ʻē aʻe. Ke mākaukau no ka puʻunaue ʻana, piha nā huahana a mālama ʻia i nā pono kūpono, i ke ana wela kūpono ʻoiai ke ukali nei i nā ʻōkuhi āpau e hōʻoia i ka hiki ʻana o ka huahana kiʻekiʻe kiʻekiʻe iā ʻoe. ʻAʻole hōʻike ʻia nā paukū Urolithin i ka lā i ka wā o ka halihali, hoʻopaʻa ʻana, a i ʻole ka mālama ʻana e like me ka mea e hōʻino ai i ka huahana hope.

Ke kūʻai nei i ka pauka Urolithin A a me ka pauka Urolithin B mai kā mākou halehanahana hana e hōʻoia i kahi huahana kiʻekiʻe ma nā kumukūʻai kumukūʻai.

Reference:

  1. Totiger TM, Srinivasan S, Jala VR, et al. ʻO Urolithin A, kahi Pūnaewele Kūlohelohe Novel i Target PI3K / AKT / mTOR Alanui ma Pancreatic Cancer. Mol Kukuna Ther. 2019; 18 (2): 301-311. hana: 10.1158 / 1535-7163.MCT-18-0464.
  2. ʻO Guada M, Ganugula R, Vadhanam M, Ravi Kumar MNV. ʻO Urolithin A Mitigates Cisplatin-Induced Nephrotoxicity e ka pāpā ʻana i ka Renal Inflammation a me Apoptosis i kahi Model Rat Model. ʻO J Pharmacol Exp Ther. 2017; 363 (1): 58-65. hana: 10.1124 / jpet.117.242420.
  3. Juan Carlos Espín, Mar Larrosa, María Teresa García-Conesa, Francisco Tomás-Barberán, "Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derid Metabolites: The Evidence So Far", Evidence-Base Complementary and Alternative Medicine, vol. 2013, ʻAoʻao ID 270418, 15 ʻaoʻao, 2013. https://doi.org/10.1155/2013/270418.
  4. Lee G, Park JS, Lee EJ, Ahn JH, Kim HS. ʻO nā anti-inflammatory a me nā ʻano hana antioxidant o urolithin B i microglia i hoʻoheheʻe ʻia. Phytomedicine. 2019; 55: 50-57. hana: 10.1016 / j.phymed.2018.06.032.
  5. Han QA, Yan C, Wang L, Li G, Xu Y, Xia X. Urolithin A hoʻonāukiuki i ka hopena endothelial ox-LDL i hoʻopili ʻia e ka hoʻololi ʻana i ke ala microRNA-27 a me ERK / PPAR-γ. ʻO Mol Nutr Meaʻai Res. 2016; 60 (9): 1933-1943. hana: 10.1002 / mnfr.201500827.