α-ketoglutaric (328-50-7) (71686-01-6) - hale hana mea hana

α-ketoglutaric

Loaʻa iā Cofftek ka hiki ke hana i ka nui a me ka lako o Calcium 2-oxoglutarate a me Alpha-Ketoglutaric Acid ma lalo o ke ʻano o cGMP.

ʻO kahi hae Cofttek

E kūʻai i ka pauka α-ketoglutaric

Hoʻoiho i nā kumuwaiwai

He aha ka Acid Alpha-Ketoglutaric (328-50-7)?

ʻO ka Alpha-ketoglutaric acid kahi hui olaola i loaʻa kūlohelohe i ke kino o ke kanaka. Loaʻa pū kekahi ma ke ʻano he papaʻai meaʻai, alpha-ketoglutaric acid he kī nui i ka pōʻai Krebs (kahi moʻo o nā hopena kemika i hoʻohana ʻia e hoʻokuʻu i ka ikehu i mālama ʻia). Hoʻolako ʻia nā mea hoʻopili a Alpha-ketoglutaric acid e hāʻawi i nā pono olakino like ʻole, e like me ka hoʻomaikaʻi ʻana i ka haʻuki a me ka hoʻomaikaʻi ʻana i ka metabolism.

ʻO ka Alpha-Ketoglutaric Acid (328-50-7) keu pono

Me kēlā ʻōlelo, ua kuhi ʻia kekahi mau haʻawina mua i nā pono kūpono o ka alpha-ketoglutaric acid supplementation. Eia ka ʻōlelo a kekahi o ka noiʻi i kēia manawa.
ʻO ka maʻi maʻi Kidney
Ua hoʻohana ʻia ka alpha-ketoglutaric acid mai ka hopena o ka makahiki 1990 e kōkua i ka wāwahi a hoʻopaʻa ʻana i ka protein i ka poʻe ma ka hemodialysis e koi ana i kahi meaʻai haʻahaʻa-protein. Hōʻike nā hōʻike hou e hiki ke hoʻopaneʻe i ka pono no ka dialysis i nā poʻe me ka maʻi maʻi maʻi maʻi maʻi (CKD).

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Punawai Haumana

PubMed Central

Ua mahalo nui ʻia mai ka National Institutes of Health
E hele i ke kumu

Wahi a kahi noiʻi 2017 ma ka puke pai PLoS One, ua ʻike nā mea noiʻi a hahai i ka poʻe 1,483 me ka CKD kiʻekiʻe i hoʻohana i ka mea hoʻohui alpha-ketoglutaric acid i kapa ʻia ʻo Ketosteril. ʻO ka awelika lōʻihi o ka hahai ʻana he 1.57 mau makahiki.
Ke hoʻohālikelike ʻia me kahi hui like ʻole o ka poʻe ʻaʻole i lawe i ka mea hoʻohui, ʻoi aku ka liʻiliʻi o ka poʻe i hana i ka dialysis lōʻihi. Hoʻonui wale ʻia nā pōmaikaʻi i ka poʻe i lawe ma mua o 5.5 papa i kēlā me kēia lā, e hōʻike ana i ka hopena o ka hopena.
ʻOiai nā hopena maikaʻi, ʻaʻole maopopo i ke ʻano o ka alpha-ketoglutaric acid i hoʻohālikelike ʻia i nā mea hana ʻē aʻe o ka supplement. Pono e noiʻi hou aku.

. Ola olakino
Manaʻo ʻia nā mea hoʻohui waikawa alpha-ketoglutaric he anticatabolic, ʻo ia hoʻi e lohi a pale a i ʻole catabolism (ka haki ʻana o nā ʻiʻo). Ma ka ho'ākākaʻana, ua kū'ē ke kaʻina hana catabolic i kahi kaʻina anabolic (kahi i kūkuluʻia ai nā kiko).
Ua hōʻike ʻia kahi noiʻi 2012 ma ka Italian Journal of Animal Science ua pale ka alpha-ketoglutaric acid i ka haki ʻana o nā ʻōpū i nā ʻiole lab i hānai ʻia i ka meaʻai ʻole protein no 14 mau lā. Ma mua o ka loaʻa ʻana o ka pōʻino i ka villi e like me ka manamana lima o ka ʻōpū—ka hopena i manaʻo ʻia—ʻaʻohe pōʻino ʻike ʻia o nā ʻiole i hānai ʻia i ka waikawa alpha-ketoglutaric i hoʻohālikelike ʻia me nā ʻiole ʻaʻole.
Eia kekahi, ua hiki i nā ʻiole ke mālama i ka ulu maʻamau me ka nele o ka protein. Hāʻawi ʻia nā dosis kiʻekiʻe i nā hopena maikaʻi aʻe.
ʻIke ʻia nā ʻike e kākoʻo i nā hopena anticatabolic o ka alpha-ketoglutaric acid. Ma waho aʻe o kāna noi ʻana i ka maʻi maʻi maʻi maʻi, hiki i ka alpha-ketoglutaric acid ke kōkua i ka poʻe me ka toxemia intestinal a me nā maʻi malabsorption e like me ka maʻi celiac. Pono e noiʻi hou aku.

. Hana ʻAtletic
Ma ka hoʻohālikelike ʻana, ʻike ʻia nā hopena anticatabolic o ka alpha-ketoglutaric acid i ka wā i hoʻohana ʻia no ka ulu ʻana o ka ʻiʻo a me ka hana haʻuki.
Wahi a kahi noiʻi 2012 ma ka Journal of the International Society of Sports Nutrition, ʻaʻohe hopena koʻikoʻi o ka alpha-ketoglutaric acid i ka ikaika o ka ʻiʻo a i ʻole ka hoʻoikaika ʻana i ka hoʻomanawanui i nā kāne 16 i hana ʻia me kahi hoʻomaʻamaʻa kūʻē kūʻē.

(2)↗

Punawai Haumana

PubMed Central

Ua mahalo nui ʻia mai ka National Institutes of Health
E hele i ke kumu

No kēia noiʻi ʻana, hāʻawi ʻia ka hapalua o nā kāne i 3,000-miligrams (mg) o ka alpha-ketoglutaric acid, aʻo ka hapa ʻē aʻe i hāʻawi ʻia i kahi placebo 45 mau minuke ma mua o ka hana ʻana i ka papa paʻi a me nā hoʻomaʻamaʻa wāwae wāwae. I ka pule aʻe, ua hoʻohuli ʻia nā mea hoʻohui, me kēlā me kēia hapalua e loaʻa i ka lāʻau lapaʻau ʻē aʻe.
Hoʻokumu ʻia ka hana haʻuki ma luna o ka nui o ka hoʻouka ʻana (TLV) o nā hoʻomaʻamaʻa i hana ʻia me ka puʻuwai ma mua a ma hope o ka hoʻoikaika kino. ʻO ka mea i hōʻike ʻia e kēia mau ʻike ʻo ka nele o ka pane catabolic ʻaʻole like ia me ka pane anabolic, ʻoi aku ka nui ma waena o nā mea pāʻani.

Hoʻohana ʻo Alpha-Ketoglutaric Acid (328-50-7)?

I ka ʻoki ʻana i ka naʻau, hāʻawi ʻia ka alpha-ketoglutaric acid i kekahi manawa me ka intravenously (i loko o kahi vein) e hōʻemi i ka pōʻino i ka ʻiʻo o ka naʻau ma muli o ke kahe ʻana o ke koko. ʻO ka hana ʻana pēlā hiki ke hoʻomaikaʻi i ke kahe koko i ka puʻupaʻa ma hope o ke ʻoki ʻana.
ʻAʻole maopopo loa kona hoʻohana ʻana i mea hoʻohui. Manaʻo nā mea lapaʻau ʻē aʻe e hiki i ka alpha-ketoglutaric acid ke mālama a pale paha i nā ʻano olakino like ʻole, e like me:
  • Nā Cataracts
  • ʻO ka maʻi maʻi kīkiʻi
  • Hepatomegaly (hoʻonui ākea)
  • Hōʻemi kūpuna
  • ʻUshpala waha
  • Osteoporosis
  • ʻO Tendinopathy
  • ʻO nā maʻi ʻehā
Ma muli o kāna kuleana i ka hoʻokuʻu ʻana i ka ikehu i mālama ʻia, kūʻai pinepine ʻia ka alpha-ketoglutaric acid ma ke ʻano he mea hoʻohui haʻuki. Ke ʻōlelo nei kekahi poʻe kākoʻo e hiki ke hoʻolōʻihi i ka ʻelemakule i ka hopena antioxidant.

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Punawai Haumana

PubMed Central

Ua mahalo nui ʻia mai ka National Institutes of Health
E hele i ke kumu

E like me ka mea maʻamau me nā mea hoʻopihapiha e koi ana e mālama i nā kūlana pili ʻole he nui, nāwaliwali nā hōʻike e kākoʻo ana i kēia mau koi. ʻO kekahi, e like me nā waiwai "anti-aging" o ka mea hoʻohui (e pili ana i kahi noiʻi 2014 e pili ana i nā ilo nematode), ka palena i ka mea hiki ʻole.

ʻO Alpha-Ketoglutaric Acid (328-50-7) nā mea hana

Loaʻa nā mea hoʻopihapiha alpha-ketoglutaric acid i ka papa, capsule, a me ka pauka hoʻokumu ʻia a hiki ke loaʻa koke ma ka pūnaewele a i ʻole ma nā hale kūʻai kūikawā i nā meaʻai meaʻai.
ʻAʻohe alakaʻi āpau no ka hoʻohana kūpono ʻana i nā waikawa alpha-ketoglutaric. Kūʻai maʻamau ʻia nā mea hoʻohui i nā dosage mai ka 300 milligrams (mg) a i ka 1,000 mg i lawe ʻia i hoʻokahi lā i kēlā me kēia lā me ka ʻai ʻole a i ʻole. Ua hoʻohana ʻia nā dosis a hiki i 3,000 mg i nā haʻawina me ka ʻole o nā hopena ʻino.

ʻO Alpha-Ketoglutaric Acid (328-50-7) nā hopena ʻē aʻe

Manaʻo ʻia ka alpha-ketoglutaric acid i palekana a ʻae ʻia. ʻO nā haʻawina e noiʻi ana i nā hopena o ka alpha-ketoglutaric acid i hōʻike i nā hōʻailona ʻino ma hope o ʻekolu mau makahiki o ka hoʻohana ʻana.
Ma ke ʻano he pūhui i hana ʻia mai nā waikawa amino pono ʻole, alpha-ketoglutaric acid ʻaʻole ia he mea e hiki ai iā ʻoe ke overdose. ʻO nā mea ʻē aʻe i loko o ke kino e hoʻokuʻu ʻia i loko o ka mimi a i ʻole e wāwahi ʻia i loko o nā poloka kūkulu hale amino acid no nā kumu ʻē aʻe.

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Punawai Haumana

PubMed Central

Ua mahalo nui ʻia mai ka National Institutes of Health
E hele i ke kumu

Me kēlā ʻōlelo, ʻaʻole i hoʻokumu ʻia ka palekana o ka alpha-ketoglutaric acid i nā wahine hāpai, nā makuahine hānai, a me nā keiki. Loaʻa kēia i nā keiki me nā maʻi maʻi metabolism e like me ka hemahema alpha-ketoglutarate dehydrogenase (kahi i hoʻokiʻekiʻe ʻia nā pae alpha-ketoglutaric acid).

No ke kūʻai aku ka paukū Alpha-Ketoglutaric Acid (Kahi e kūʻai ai i ka pauka Alpha-Ketoglutaric Acid i ka nui)

ʻOliʻoli kā mākou ʻoihana i nā pilina lōʻihi e ko mākou mea kūʻai aku no ka mea ke nānā aku nei mākou i ka lawelawe o ka mea kūʻai aku a hāʻawi i nā huahana maikaʻi. Inā makemake ʻoe i kā mākou huahana, maʻalahi mākou me ka hoʻokaʻawale ʻana i nā kauoha e kūpono i kāu pono kūikawā a me ko mākou wikiwiki wikiwiki i nā kauoha e hōʻoia ʻoe e hoʻāʻo nui i kā mākou huahana i ka manawa. Hoʻomaopopo pū mākou i nā lawelawe i hoʻohui ʻia. Loaʻa mākou i nā nīnau a me ka ʻike e kākoʻo i kāu ʻoihana.
ʻO mākou kahi mea hoʻolako ʻoihana Alpha-Ketoglutaric Acid pauka no nā makahiki he nui, hāʻawi mākou i nā huahana me ke kumukūʻai hoʻokūkū, a ʻo kā mākou huahana ka mea kiʻekiʻe loa a ke hoʻokō nei i ka hoʻāʻo kūʻokoʻa kūʻokoʻa e hōʻoia i ka palekana no ka ʻai ʻana a puni ka honua.

Reference:

  1. Abrahamams JP, Leslie AG, Lutter R, Walker JE. Kūlana ma 2.8 A hoʻonā o F1-ATPase mai ka mitochondria puʻuwai bovine. Kūlohelohe. 1994; 370: 621-628. hana: 10.1038 / 370621a0.
  2. Alpers DH. Glutamine: ke kākoʻo nei ka ʻikepili i ke kumu no ka glutamine supplementation i loko o ke kanaka? Gastroenterology. 2006; 130: S106 – S116. hana: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Muscle a me nā plasma amino acid ma hope o ka ʻeha. ʻO Ann Surg. 1980; 192: 78-85. hana: 10.1097 / 00000658-198007000-00014.