α-ketoglutaric

Loaʻa iā Cofftek ka hiki ke hana i ka nui a me ka lako o Calcium 2-oxoglutarate a me Alpha-Ketoglutaric Acid ma lalo o ke ʻano o cGMP.

He aha ka Acid Alpha-Ketoglutaric (328-50-7)?

ʻO ka Alpha-ketoglutaric acid kahi hui olaola i loaʻa kūlohelohe i ke kino o ke kanaka. Loaʻa pū kekahi ma ke ʻano he papaʻai meaʻai, alpha-ketoglutaric acid he kī nui i ka pōʻai Krebs (kahi moʻo o nā hopena kemika i hoʻohana ʻia e hoʻokuʻu i ka ikehu i mālama ʻia). Hoʻolako ʻia nā mea hoʻopili a Alpha-ketoglutaric acid e hāʻawi i nā pono olakino like ʻole, e like me ka hoʻomaikaʻi ʻana i ka haʻuki a me ka hoʻomaikaʻi ʻana i ka metabolism.

ʻO ka Alpha-Ketoglutaric Acid (328-50-7) keu pono

Me kēlā ʻōlelo, ua kuhi ʻia kekahi mau haʻawina mua i nā pono kūpono o ka alpha-ketoglutaric acid supplementation. Eia ka ʻōlelo a kekahi o ka noiʻi i kēia manawa.
ʻO ka maʻi maʻi Kidney
Ua hoʻohana ʻia ʻo Alpha-ketoglutaric acid mai ka hopena o ka makahiki 1990 e kōkua i ka wāwahi ʻana a me ka omo ʻana i ka protein i ka poʻe ma hemodialysis e koi ai i ka papaʻai protein haʻahaʻa. Hōʻike nā hōʻike hou e lohi paha ia i ka pono o ka dialysis i ka poʻe me ka maʻi puʻuwai mau loa (CKD). Wahi a kahi noi 2017 i ka puke pai PLoS One, ua hoʻomaopopo a ua ukali ka poʻe noiʻi me 1,483 poʻe me ka holomua CKD nāna i hoʻohana i kahi alpha-ketoglutaric acid supplement i kapa ʻia ʻo Ketosteril. ʻO ka lōʻihi o ke kau ʻana o 1.57 mau makahiki. Hoʻohālikelike ʻia i kahi kūlike o kēlā me kēia kanaka i lawe ʻole i ka pākuʻi, ʻo ka poʻe i hana ʻoi aku ka liʻiliʻi e koi i ka dialysis lōʻihi. Hoʻonui wale ʻia nā pōmaikaʻi i ka poʻe i lawe ʻoi aku ma mua o 5.5 mau papa i kēlā me kēia lā, e hōʻike ana i nā hopena i ka hilinaʻi ʻia me ka hopena ʻOiai nā hopena maikaʻi, maopopo ʻole ke ʻano o ka hana a ka alpha-ketoglutaric acid i ka hoʻohālikelike ʻana i nā mea hana ʻē aʻe a ka supplement. Pono hou kahi noiʻi.

. Ola olakino
Manaʻo ʻia ʻo nā Alpha-ketoglutaric acid supplement e anticatabolic, ʻo ia hoʻi ka lohi a pale a i ʻole catabolism (ka haki o nā aʻa). Ma ka wehewehe ʻana, ʻokoʻa kahi kaʻina catabolic i kahi kaʻina anabolic (kahi i kūkulu ʻia ai nā pūnaewele). Ua hōʻike ʻia kahi noi ma 2012 i ka Italian Journal of Animal Science ua pale ka alpha-ketoglutaric acid i ka haki ʻana o nā ʻōpū i nā ʻiole lab i hānai ʻia i kahi papaʻai protein ʻole no 14 mau lā. Ma mua o ka loaʻa ʻana o ka poino i ka villi-like villi o nā ʻōpū-ʻo ka hopena i manaʻo ʻia - ua ʻai nā ʻiole i ka alpha-ketoglutaric acid ʻaʻohe mea i ʻike ʻia ke hoʻohālikelike ʻia me nā ʻiole ʻaʻole. Eia kekahi, ua hāʻawi nā ʻiole i nā mea hoʻopili i hiki ke mālama i ka ulu maʻamau ʻoiai ka nui o ka nele o ka protein. Ua hāʻawi ʻia nā lāʻau kiʻekiʻe i nā hopena i ʻoi aku ka maikaʻi. ʻIke ʻia nā mea i kākoʻo ʻia e kākoʻo i nā hopena anticatabolic acid alpha-ketoglutaric acid. Ma waho o kāna noi i nā maʻi puʻuwai mau, alpha-ketoglutaric acid hiki ke kōkua pū i ka poʻe me ka toxemia ʻōpū a me nā maʻi malabsorption e like me ka maʻi celiac. Pono hou kahi noiʻi.

. Hana ʻAtletic
Ma ka hoʻohālikelike, ʻike ʻia nā hopena anticatabolic o ka alpha-ketoglutaric acid e hāʻule pōkole ke hoʻohana ʻia no ke kumu o ka ulu ʻana o nā mākala a me ka hana haʻuki. Wahi a kahi noi 2012 i ka Ka Nūpepa o ka International Society of Sports Nutr, ʻaʻohe hopena kūpono o ka alpha-ketoglutaric acid i ka ikaika o ka mākala a i ʻole ka hoʻomanawanui i nā kāne he 16 i hana ʻia me kahi hoʻomaʻamaʻa hoʻomaʻamaʻa kūʻē. No kēia noi ʻana, ua hāʻawi ʻia ka hapalua o nā kāne i 3,000-milligrams (mg) o ka alpha-ketoglutaric acid, ʻo ka hapalua i hāʻawi ʻia i kahi placebo 45 mau minuke ma mua o ka hana ʻana i ka bench press a me nā kaomi kaomi wāwae. I ka pule aʻe, ua hoʻohuli ʻia nā mea hoʻopiha, me kēlā me kēia hapa e loaʻa ana i ka lāʻau ʻē aʻe. Hoʻokumu ʻia ka hana Athletic i ka nui o ka nui o ka ukana (TLV) o nā hana i hana ʻia i ka tandem me nā helu puʻuwai mua a ma hope o ka hoʻolālā. ʻO ka mea a kēia mau hopena i hōʻike ai ʻo ka loaʻa ʻole o ka pane catabolic ʻaʻole like ia me ka pane anabolic, ʻoi aku ma waena o nā mea haʻuki.

Hoʻohana ʻo Alpha-Ketoglutaric Acid (328-50-7)?

I ka puʻuwai puʻuwai, hāʻawi ʻia ka alpha-ketoglutaric acid i kekahi manawa i loko o ke aniani (i kahi aa) e hoʻoliʻiliʻi i ka hōʻino ʻana i ka puʻuwai puʻuwai ma muli o ke kahe o ke kahe o ke koko. ʻO ka hana ʻana pēlā e hoʻomaikaʻi ai i ke kahe o ke koko i ka hakuʻala ma hope o ke ʻoki ʻana. ʻO kāna hoʻohana ʻana ma ke ʻano he pakuʻi ua emi loa ia. Manaʻo nā mea hana ʻē aʻe hiki i ka alpha-ketoglutaric acid ke mālama a pale paha i ka nui o nā kūlana olakino, e like me:
  • Nā Cataracts
  • ʻO ka maʻi maʻi kīkiʻi
  • Hepatomegaly (hoʻonui ākea)
  • Hōʻemi kūpuna
  • ʻUshpala waha
  • Osteoporosis
  • ʻO Tendinopathy
  • ʻO nā maʻi ʻehā
Ma muli o kāna kuleana i ka hoʻokuʻu ʻana i ka ikehu i mālama ʻia, kūʻai pinepine ʻia ʻo alpha-ketoglutaric acid ma ke ʻano he hoʻokō haʻuki hoʻokō. Hōʻoiaʻiʻo kekahi mau mea kākoʻo e hiki i nā hopena antioksant supplement ke hoʻonā i ka ʻelemakule. E like me ka manawa pinepine me nā mea hoʻopihapiha e koi e mālama i nā ʻano pili pili ʻole, nāwaliwali nā hōʻike e kākoʻo ana i kēia mau koi. ʻO kekahi, e like me nā "anti-ʻelemakule" waiwai o ke kumukānāwai (hoʻokumu nui ʻia ma kahi noi 2014 e pili ana i nā ilo nematode), palena ma ka hiki ʻole.

ʻO Alpha-Ketoglutaric Acid (328-50-7) nā mea hana

Loaʻa nā kōkua kōkua alpha-ketoglutaric acid i ka papa, capsule, a me nā paukū formulate a hiki ke loaʻa koke ma ka pūnaewele a i ʻole nā ​​hale kūʻai e loea ana i nā mea hoʻopihaʻai. ʻAʻohe alakaʻi āpau no ka hoʻohana kūpono o nā alpha-ketoglutaric acid. Kūʻai kūʻai ʻia nā mea hoʻohui i nā dosages mai ka 300 milligrams (mg) a i ka 1,000 mg i lawe ʻia i kēlā me kēia lā me ka ʻai ʻole. Hoʻohana ʻia nā hana a i ka 3,000 mg i nā noi me nā hopena maikaʻi ʻole.

ʻO Alpha-Ketoglutaric Acid (328-50-7) nā hopena ʻē aʻe

Manaʻo ʻia ʻo Alpha-ketoglutaric acid ka palekana a me ka hoʻomanawanui maikaʻi ʻana. ʻO nā noiʻi e noiʻi ana i nā hopena o ka alpha-ketoglutaric acid hōʻike i kekahi mau hōʻailona maikaʻi ʻole ma hope o ʻekolu mau makahiki o ka hoʻohana. Ma ke ʻano he hui i hana ʻia mai nā amino acid pono ʻole, ʻaʻole ka alpha-ketoglutaric acid kahi waiwai e hiki ai iā ʻoe ke hoʻomāhuahua koke. E hoʻopau ʻia kekahi mea i loko o ke kino i ka mimi a i ʻole wāwahi ʻia i loko o nā poloka hale amino acid kumu no nā kumu ʻē aʻe. Me kēlā ʻōlelo, ʻaʻole i hoʻokumu ʻia ka palekana o ka alpha-ketoglutaric acid i nā wahine hāpai, nā makuahine hānai, a me nā keiki. Hoʻopili pū kēia me nā keiki me nā maʻi pūnaeho laha ʻole e like me ka hemahema alpha-ketoglutarate dehydrogenase (kahi e hoʻonui ʻia ai ka alpha-ketoglutaric acid level).

No ke kūʻai aku ka paukū Alpha-Ketoglutaric Acid (Kahi e kūʻai ai i ka pauka Alpha-Ketoglutaric Acid i ka nui)

Makemake kā mākou hui i nā pilina lōʻihi me kā mākou mea kūʻai aku no ka mea ke nānā aku mākou i ka lawelawe ʻana a ka poʻe kūʻai a hāʻawi i nā huahana maikaʻi. Inā makemake ʻoe i kā mākou huahana, maʻalahi mākou me ka maʻamau ʻana o nā kauoha e kūpono i kāu pono kikoʻī a me ko mākou manawa alakaʻi wikiwiki ma nā kauoha e hōʻoiaʻiʻo ʻoe e ʻono nui i kā mākou huahana i ka manawa kūpono. Kūleʻa pū mākou i nā lawelawe hoʻohui waiwai. Loaʻa mākou no nā nīnau lawelawe a me ka ʻike e kākoʻo i kāu ʻoihana. ʻO mākou he mea hana ʻoihana Alpha-Ketoglutaric Acid paukū no kahi mau makahiki, hoʻolako mākou i nā huahana me ke kumukūʻai hoʻokūkū, a ʻo kā mākou huahana ke kiʻekiʻe kiʻekiʻe loa a ke hana nei i nā hoʻokolohua koʻikoʻi, kūʻokoʻa e hōʻoia i ka palekana o ka ʻai ma ka honua holoʻokoʻa.

Reference:

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  2. Alpers DH. Glutamine: ke kākoʻo nei ka ʻikepili i ke kumu no ka glutamine supplementation i loko o ke kanaka? Gastroenterology. 2006; 130: S106 – S116. hana: 10.1053 / j.gastro.2005.11.049.
  3. Ashkanazi J, Carpertier Y, Michelsen C. Muscle a me nā plasma amino acid ma hope o ka ʻeha. ʻO Ann Surg. 1980; 192: 78-85. hana: 10.1097 / 00000658-198007000-00014.