ʻO Citicoline Sodium (33818-15-4)

ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) Snāʻike

Name:	ʻO Citicoline Sodium (CDP Choline Sodium)
CAS:	33818-15-4
Purity	98%
Kaulike Molecular:	C14H25N4NaO11P2
Kaumaha Molecular:	510.308 g / mol
Wahi Manaʻo:	> 240 ° C
Inoa inoa inoa inoa:	Citicoline Sodium; ʻO ka sodium Cdp-choline
Hōʻuluʻulu Manaʻo:	Sodium [[(2S,3R,4S,5S)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]2-(trimethylazaniumyl)ethyl phosphate
InChI Key:	YWAFNFGRBBBSPD-KDVMHAGBSA-M
Half Ola:	56 mau hola
Palekana:	Hoʻopauʻia i DMSO, ka Wai (Lohi iki)
Ke kūlana Mana:	Maloʻo, ʻeleʻele a ma 0 - 4 C no ka wā pōkole (mau lā a i mau pule) a i ʻole -20 C no ka wā lōʻihi (mau mahina i mau makahiki).
noi:	ʻO Citicoline Sodium kahi ʻākena neuroprotective a me ka hoʻopihapihaʻai
ʻAno:	ʻO kaʻeleʻele maloʻo

 

Citroline Sodium (33818-15-4) NMR Spectrum

Inā makemake ʻoe iā COA, MSDS, HNMR no kēlā me kēia ʻōhua o ka huahana a me nā ʻike ʻē aʻe, e ʻoluʻolu e leka uila i kā mākou luna kūʻai kūʻai.

 

He aha ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ?

ʻO Citicoline Sodium (CDP-choline Sodium, cytidine 5'-diphosphocholine) ka pauka he mea hiki ke hoʻoheheʻe ʻia i ka wai e lilo i mea mua i nā choline a me nā cytidine ma loko o ka lolo (i hoʻohuli ʻia i uridine). I nā kānaka, he mea waiwai nui ʻo Citicoline Sodium ma ke ʻano he mea nui ia e hōʻemi ai i nā maʻi kīnā ʻole neural tube, nā maʻi momona o ka ate, a me nā ʻano pathologies ʻē aʻe. ʻO CDP-choline Sodium kekahi o nā kolinine choline-piha i piha i hiki ke hoʻohui waha ʻia (ʻo nā alpha-GPC a me phosphatidylcholine) ʻelua mau choline.

 

ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) maika

Hoʻoikaika ʻo CDP-choline i ka biosynthesis o nā phospholipids kūlohelohe i nā membrane neuronal, hoʻonui i ka metabolism cerebral a hana i nā pae o nā neurotransmitters like ʻole. No laila, ua hoʻokolohua hoʻāʻo ʻia e hoʻonui ka CDP-choline i ka noradrenaline a me ka pae dopamine ma ka CNS.

Hoʻopiʻia kēia kuhi no ka pale a mālamaʻana paha i nā hemahema hoʻomanaʻo e pili ana i ke olalaʻana ma muli o kaʻoiaʻiʻo o nā molele i hoʻohuiʻia e neuroprotective a hoʻonui i ka aʻoʻana. ʻOiai eʻikeʻia ana heʻoi aʻe ka maikaʻi ma mua o ka phosphatidylcholine (PC) ma kēiaʻano, ma kahi hapa no ka hoʻonuiʻana i ka synthesis PC i loko o ka lolo, ua like konaʻano me ka mea o Alpha-GPC.

 

ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) hana

Loaʻa i kahi CDP-choline kekahi mau hoʻohana kūpono ʻē aʻe e pili ana i ka ʻike. Hoʻohana mau ʻia ia ma ke ʻano he mea hoʻonui hoʻomanaʻo hoʻomanaʻo i ka wā ʻōpio, akā naʻe me kekahi mau ʻoihana rodent e hōʻike ana he hiki kēia me ka CDP-choline waha, ʻaʻohe ʻike kanaka i ka ʻōpio i kēia manawa o ka manawa. Ua hoʻomaopopo ʻia kahi noiʻi i ka hoʻonui ʻana o ka nānā me ka hapa liʻiliʻi o ka CDP-choline (kahi e pono ai e hoʻopili hou ʻia), a ʻo CDP-choline paha kahi kuleana e like me kahi anti-addictive compound e kūʻē i nā cocaine a me (hōʻike mua e hōʻike nei) nā meaʻai pū kekahi ..

 

ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) noi

ʻO Citicoline Sodium (CDP Choline Sodium) kahi pauka neuroprotective. Hana ia e ka hoʻomaikaʻi ʻana i ke kamaʻilio pūnaewele, hoʻoulu i ka synthesite o SAMe, a me ka hoʻonui ʻana i ka metabolism glucose. ʻO Citicoline Sodium (CDP Choline Sodium) ka pauka he nucleotide kūlohelohe; waena ma ke ala nui o ka lecitin biosynthesis. Neuroprotective. Hoʻohana ʻia ia i ka mālama ʻana i ka maʻi ischemic a me ke poʻo trauma. Nā huahana Neuroprotective. Hōʻike ʻo Citicholine i nā hopena pale i ka ischemia cerebral, ʻeha lolo ʻeha, a me nā maʻi hoʻomanaʻo. I kēia manawa i hōʻike i ka pono e kūʻē i ka dementia ke hāʻawi ʻia me AchEIs (Acetylcholinesterase inhibitor). Hōʻike i ka Neuroprotective, ka hana acnticonvulsant a me ka hopena sedative i kahi mahele o 150mg / kg i nāʻiole. Hōʻike ʻia ka pale e kū ʻole i ka alumini i ka noʻonoʻo ʻole i nāʻiole e hoʻoliʻiliʻi ana i ka pae glutamate kiʻekiʻe, oxidativestress a me NO overproduction i ka hippocampus.

 

ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) ka lehu no ka kuai

(Kahi e kūʻai ai i ka Sodium Citicoline (CDP Choline Sodium)(33818-15-4) ka pauka i ka nui)

ʻOliʻoli kā mākou ʻoihana i nā pilina lōʻihi e ko mākou mea kūʻai aku no ka mea ke nānā aku nei mākou i ka lawelawe o ka mea kūʻai aku a hāʻawi i nā huahana maikaʻi. Inā makemake ʻoe i kā mākou huahana, maʻalahi mākou me ka hoʻokaʻawale ʻana i nā kauoha e kūpono i kāu pono kūikawā a me ko mākou wikiwiki wikiwiki i nā kauoha e hōʻoia ʻoe e hoʻāʻo nui i kā mākou huahana i ka manawa. Hoʻomaopopo pū mākou i nā lawelawe i hoʻohui ʻia. Loaʻa mākou i nā nīnau a me ka ʻike e kākoʻo i kāu ʻoihana.

He ʻoihana mākou ʻO Citicoline Sodium (CDP Choline Sodium)(33818-15-4) mea hoʻolako i ka pauka no nā makahiki he nui, hoʻolako mākou i nā huahana me ke kumukūʻai hoʻokūkū, a ʻo kā mākou huahana ke kiʻekiʻe kiʻekiʻe loa a hana i nā hoʻokolohua koʻikoʻi, kūʻokoʻa e hōʻoia i ka palekana o ka ʻai ma ka honua holoʻokoʻa.

 

E hoʻomaopopo '

[1] Tyurenkov IN, Kurkin DV, Bakulin DA, Volotova EV, Chafeev MA. [He hana Cerebroprotective o metformin, gosogliptin, citicoline a me kahi agonist GPR119 i loko o ka ischemia cerebral ma lalo o ka maʻi mellitus hoʻokolohua. Zh Nevrol Psikhiatr Im SS Korsakova. 2017; 117 (12. Vyp. 2): 53-59. doi: 10.17116 / jnevro201711712253-59. Lukia. PubMed PMID: 29411746.

[2] Jiang JJ, Xie YM, Zhang Y, Zhang YK, Wang ZM, Han B. [Nā kino lāʻau lapaʻau o nā hōʻola shuxuening e hoʻomaʻamaʻa ana i ka noi ʻana i ka cerebral infarction research e pili ana i ke kau inoa). Zhongguo Zhong Yao Za Zhi. 2016 Dec; 41 (24): 4516-4520. doi: 10.4268 / cjcmm20162407. Pākē. PubMed PMID: 28936832.

[3] Liu Y, Wang J, Xu C, Chen Y, Yang J, Liu D, Niu H, Jiang Y, Yang S, Ying H. He nui i loko o kā CDP-koline huaʻāmeʻa e hoʻohana ana i ka hāmeʻa e ATP donor module. ʻO kā Microbiol Biotechnol. 2017 Feb; 101 (4): 1409-1417. doi: 10.1007 / s00253-016-7874-0. Epub 2016 Oct 13. PubMed PMID: 27738720.

[4] ʻO Giménez R, Raīch J, Aguilar J (Nov 1991). "Nā loli i ka dopamine striatum o ka lolo a me nā mea loaʻa acetylcholine i hoʻokomo ʻia e ka CDP-choline maʻi maʻamau o nā ʻiole ʻelemakule". Ka Nūpepa Pelekikena ʻo British Pharmacology. 104 (3): 575-8. hana: 1111 / j.1476-5381.1991.tb12471.x. PMC1908237. PMID1839138.

[5] ʻO Tardner, P. (2020-08-30). "Ka hoʻohana ʻana o citikoline no ka hoʻomaʻamaʻa ʻana i ka hoʻohaʻahaʻa o ka naʻau a me ka hōʻino ʻana o ka naʻau: A meta-analysis of pharmacological literities • International Journal of Environmental Science & Technology". Ka Nūpepa'Āina o kaʻEpekemaʻIpekema & Technology. Ua kiʻi ʻia 2020-08-31.

 

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