ʻO Nikotinamide Riboside Chloride (NR) (23111-00-4)

Nicotinamide Riboside Chloride (NR) (23111-00-4) wikiō

Nikotinamide Riboside Chloride (NR) Snāʻike

He aha ia ʻo Nicotinamide Riboside Chloride (NR) CAS 23111-00-4?

ʻO ka riboside Nicotinamide, i ʻike ʻia ʻo NR a me SRT647, he ʻano pyridine-nucleoside o ka vitamini B3 e hana ana ma ke ʻano o ka hana loea ma nicotinamide adenine dinucleotide a i ʻole NAD +. NR poloka degeneration o beast dorsal root ganglion neurons ex vivo a pale aku me ka pale ʻana i ka lohe ʻole i nā kani leo e pili ana i nā kiʻina ola. Hoʻopili ʻo Nicotinamide riboside i ka ʻiʻo, neural a me melanocyte stem cell senescence. ʻO ka hoʻonui ʻia ʻana o ka mau mākala me nā isika ua mālama ʻia ma hope o ka mālama ʻana me ka nicotinamide riboside, e alakaʻi ana i ka manaʻo e hiki ai ke hoʻomaikaʻi hou i nā hanana hou e like me ka palaka, aʻae, a me nā puʻuwai. ʻO Nicotinamide riboside e hoʻohaʻahaʻa ana i ka hoʻokahe koko a me nā momona momona i ka prediabetic a me nā hoʻohālikelike 2 ʻano maʻamau no ka pale ʻana i ka hoʻomohala ʻana o ka maʻi peripheral diabetes. Nānā: ʻO Nikotinamide Riboside chloride he pākuʻi α / β.

ʻO Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 mau pōmaikaʻi

ʻO nā nucleosides Nicotinamide he mea kūpono o ka nicotinamide adenine dinucleotide (NAD) a i hōʻike i kahi kumu o ka vitamin B3. Ua hōʻike ʻia nā noiʻi hou ʻana i ka lawe ʻana i ka nui o nā nukleine ʻo Nikotinamide kūlohelohe maoli i loko o nā meaʻai e hiki ke hāʻawi i nā pono olakino hou. No ka hoʻohālikelike, ua hoʻokomo ʻia nā nukleinamide nicotinamide i ka hoʻonui ʻana i ka hoʻolālā NAD kiko a me ka hoʻomoe ʻana i ka naʻau o ka insulin a me ka hoʻomaikaʻi ʻana i ka hana sirtuin. ʻO kona hiki i ka hoʻonui ʻana i ka hana NAD e kuhikuhi ana i ka nucleotides nicotinamide hiki ke hoʻomaikaʻi i ke olakino mitochondrial, hōʻeuʻeu i ka hana mitochondrial, a koi aku i ka hana o nā mitochondria hou. ʻO nā haʻawina ʻē aʻe me ka hoʻohana ʻana i nā nucleotides nicotinamide i loko o ka maʻi maʻi Alzheimer ua hōʻike ʻia ka bioavailable i ka lolo a hāʻawi i ka neuroprotection ma ka hoʻoulu ʻana i ka lolo NAD synthesis.

Hiki pū nō ke Nicotinamide Riboside Chloride i ka hōʻemi ʻana i ka momona: Ua hōʻike ʻia nā noiʻi na ka hoʻonui ʻana i ka ikehu i ka ikehu, hiki iā ʻoe ke hōʻemi i ka momona nui i ka momona momona e koi ai ke lilo. I mea e loiloi ai i ka ʻoihana molopihamo nikotinamide o ka NR e hoʻolaha ana i ka hoʻolilo momona, ua ʻike ʻia e nā mea noiʻi ka hana mitochondrial hana i pili me ka caloric intake, ka hana, nā ʻōpū, ka ʻili lehelehe, ka hoʻomaha ʻana i ka metabolic rate, ka hui ʻana o ke kino, ka hoʻohuihui glucose, ka naʻau ʻokoʻa a me nā ʻano biochemical a me ka metabolomics wahī. ʻO kēia mau ikepili a me ka mīkini hōʻano hou o ka lawe ʻana ma o ka malabsorption, ka hoʻopuka ʻana i nā māka pili ola no ka hoʻopili ʻana. Ua hōʻike ʻia e nā mea noiʻi, ʻoi aku ka nui o nā mea i hāʻawi ʻia i nā pōpoki nicotinamide ʻoi aku ka nui o ka momona me nā mice ʻaʻole i hoʻohui i ka nicotinamide

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Hoʻolaha i ka hana?

ʻO Nicotinamide Riboside Chloride (NR) nukleosida ka mea pehu o ka nikotinamide adenine dinucleotide (NAD) a i lilo i kumu no nā huaora B3. Ua hōʻike ʻia nā noiʻi hou ʻana i ka lawe ʻana i ka nui o nā nukleine ʻo Nikotinamide kūlohelohe maoli i loko o nā meaʻai e hiki ke hāʻawi i nā pono olakino hou. No ka hoʻohālikelike, ua hoʻokomo ʻia nā nukleinamide nicotinamide i ka hoʻonui ʻana i ka hoʻolālā NAD kiko a me ka hoʻomoe ʻana i ka naʻau o ka insulin a me ka hoʻomaikaʻi ʻana i ka hana sirtuin. ʻO kona hiki i ka hoʻonui ʻana i ka hana NAD e kuhikuhi ana i ka nucleotides nicotinamide hiki ke hoʻomaikaʻi i ke olakino mitochondrial, hōʻeuʻeu i ka hana mitochondrial, a koi aku i ka hana o nā mitochondria hou. ʻO nā noiʻi ʻē aʻe e hoʻohana ana i nā nucleotides nicotinamide i loko o ka maʻi maʻi Alzheimer ua hōʻike ʻia ka bioavailable i ka lolo a hāʻawi i ka neuroprotection e ka hoʻoulu ʻana i ka lolo NAD synthesis ..

Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 noi

Ua hōʻike ʻia nā haʻawina mua a ʻo ka hoʻohui ʻana o ka ribotine nicotinamide ʻaʻole hiki ke hoʻonui wale i nā pae NAD + me ka maluhia, akā hiki nō hoʻi i ke hoʻonui ʻana i ka hoʻohana ʻana o NAD + i nā kānaka, ʻaʻole hiki ke loaʻa kekahi mau huahelu B3.Studies i hōʻike ʻia i ka manawa o ka ribotinamide ka puka i loko o ka pūlima, hoʻololi koke ke kino iā NAD +. ʻO kēia NAD + laila hoʻoulu i ke kaʻina o ka hoʻomakaʻina intacellular i ka hoʻokumu ʻana i ka ikehu ma mitochondria

Hiki i ka Nicotinamide Riboside Chloride ke hoʻonui i ka hana mitochondrial, ka mea i hōʻike ʻia e hoʻoikaika ai i ka hōʻike o nā protein chain mitochondrial protein, hoʻonui i ka hiki ke mitochondrial membrane maʻa, a hoʻonui i ka helu o ka hanu o ka oxidative a me nā pae ATP intracellular. Hiki ke mālama pū ʻia e nā kiʻekiʻe kiʻekiʻe o ka mitochondrial regeneration. Hoʻololi ka hana Mitochondrial i ko mākou wā e ulu nei, a ʻo ia ka hōʻailona o ka wā o nā ʻōhua ololi e loaʻa nei iā mākou. Hiki i ka NR ke hoʻonui i ka hana o ka mitochondria a hoʻokaʻawale i ka senescence o nā cell stem.

Nikotinamide Riboside Chloride (NR) ka lehu no ka kuai(Ma ke kūʻai aku i ka pulupulu Nicotinamide Riboside Chloride (NR) paukū

ʻOliʻoli kā mākou ʻoihana i nā pilina lōʻihi e ko mākou mea kūʻai aku no ka mea ke nānā aku nei mākou i ka lawelawe o ka mea kūʻai aku a hāʻawi i nā huahana maikaʻi. Inā makemake ʻoe i kā mākou huahana, maʻalahi mākou me ka hoʻokaʻawale ʻana i nā kauoha e kūpono i kāu pono kūikawā a me ko mākou wikiwiki wikiwiki i nā kauoha e hōʻoia ʻoe e hoʻāʻo nui i kā mākou huahana i ka manawa. Hoʻomaopopo pū mākou i nā lawelawe i hoʻohui ʻia. Loaʻa mākou i nā nīnau a me ka ʻike e kākoʻo i kāu ʻoihana.

He lāʻau loea ʻo mākou ʻo Nikotinamide Riboside Chloride (NR) i mau makahiki he nui, hoʻolako mākou i nā huahana me ke kumu kūʻai, a ʻo kā mākou huahana o ke ʻano kiʻekiʻe loa a ma lalo o ka hoʻomaʻamaʻa kūʻokoʻa, kūʻokoʻa kūʻokoʻa e hōʻoia ai ka palekana no ka hoʻohana ʻana ma ka honua.

E hoʻomaopopo '

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• ʻO Bogan KL, Brenner C. Nicotinic acid, nicotinamide, a me ka ribotine nikotinamide: kahi loiloi molekole o NAD + precursor huaora ma ka meaʻai o ke kanaka. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Hoʻopau ʻana. PubMed PMID: 18429699.
• ʻO Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ma ke ʻano he cell-intrinsic, ke alakaʻi nei i ka mea hoʻokele e hoʻolalepa ai ka momona: kemika a me ka loiloi metabolic o nā hoʻololi acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Hoʻopau ʻana. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.