NR pauka (23111-00-4)

NR pauka (23111-00-4) wikiō

 

Nikotinamide Riboside Chloride (NR) Snāʻike

Name:	ʻO Nicotinamide Riboside Chloride (NR)
CAS:	23111-00-4
Purity	98%
Kaulike Molecular:	C11H15ClN2O5
Kaumaha Molecular:	290.7 g / mol
Wahi Manaʻo:	115-125 ℃
Inoa inoa inoa inoa:	3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Hōʻuluʻulu Manaʻo:	Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, ʻĀina / β hui
InChI Key:	YABIFCKURFRPPO-FSDYPCQHSA-N
Half Ola:	2.7 hola
Palekana:	Hoʻopau maikaʻiʻia i DMSO, Methanol, Wai
Ke kūlana Mana:	0 - 4 C no ka wā pōkole (mau lā a i mau pule), a i ʻole -20 C no ka wā lōʻihi (mahina)
noi:	Ua hoʻopiʻi ʻia ʻo Nikotinamide riboside he ʻano hou pyridine-nucleoside o ka vitamin B₃ e hana ana ma ke ʻano o ka nicotinamide adenine dinucleotide a i ʻole NAD +.
ʻAno:	Holo ke keʻokeʻo a ʻike i ka pauka Pale ʻula

 

ʻO Chotide ʻO Nikotinamide

ʻO ke kino o ke kanaka kahi hanana paʻakikī i kūkulu ʻia i nā pūnaewele, nā aʻa, a me nā ʻōnaehana ʻōnaehana. Hoʻonohonoho ʻia a kōkua ʻia ka hana kūpono o nā hunaola a me nā aʻa i ke kino a kōkua ʻia e nā kemika like ʻole, nā enzyme, a me nā meaola. Hiki i kekahi o kēia ke hana i ke kino iā lākou iho, a pono e hoʻopau ʻia kekahi. No laila, aia kēia mau meaola i ke ʻano o ka papaʻai a me nā mea hoʻohui. ʻO kekahi o kēia mau mea i hiki ke kōkua i ka hoʻōla a hoʻoponopono i ke kino i kapa ʻia ʻo nicotinamide riboside chloride (NR). Kōkua ia e hoʻonui i ka nui o ka nicotinamide adenine dinucleotide (NAD +) i loko o ke kino.

 

He aha ka hana a Nicotinamide Riboside Chloride?

ʻO Nicotinamide Riboside Chloride, i kapa ʻia ʻo NR, he pyridine nucleoside o ka huaora B3. Hana ia ma ke ʻano he forerunner no ka nikotinamide adenine dinucleotide (NAD +). Loaʻa iā ia ma ke keʻokeʻo keʻokeʻo i ka pauda kala melemele. ʻO ia kekahi o nā mea i aʻo mua ʻia ʻo NAD + precursors ʻoiai he nui nā pono olakino. 

Pili ʻo NAD + i kekahi o nā mea nui e hana ana i nā ʻano homeostasis ʻokoʻa i ke kino. Hiki ke kōkua i ka mālama ʻana i ke kino i ke olakino, hoʻonui i ke ola o nā hunaola, kōkua i ka hana ʻana i nā hana metabolic like ʻole a kōkua i ka mālama ʻana i nā ʻano pathophysiology i ke kino. 

Ua hōʻike ka NR pauma i ka maikaʻi ma ke ʻano he piʻi piʻi ʻana i nā ʻano maʻi like ʻole. I nā koina kiʻekiʻe, hiki i ka NR ke mālama i nā kūlana e like me nā maʻi maʻi maʻi, nā maʻi neurodegenerative, nā maʻi musculoskeletal, a me nā maʻi metabolic. Ua hōʻike ʻia ʻo NR e hoʻopaneʻe i ka ʻelemakule o nā pūnaewele a hoʻolōʻihi i ko lākou ola. Loaʻa ia i nā huahana meaʻai e like me ka iʻa, ka moa, nā hua manu, ka waiū, a me ka palaoa. 

 

He aha ka hana a Nicotinamide Riboside Chloride?

I mea e ʻike ai i ka hana a ka nikotinamide riboside chloride, pono mākou e hoʻomaopopo mua i ka adotine dinucleotide a nicotinamide a i ʻole NAD +. 

ʻO NAD + kahi coenzyme nui i ke kino o ke kanaka. Hana ia i ka hana ʻana i nā ala metabolic ʻokoʻa. Pono ke kū ʻana i ke kino no ka mālama ʻana i nā ʻano pathologies. Mālama pū kekahi ia i ka ikehu no ka lolo, nā hunaola a me nā mākala.

ʻO ka nui o ka NAD + i hiki ke kiʻi ʻia mai nā kumuwaiwai liʻiliʻi he liʻiliʻi loa. ʻAʻole lawa kēia no nā keena he nui o ke kino e hoʻohana ai. No laila e hana ai, hele ke kino i nā ala like ʻole. ʻEkolu ala nui e hiki ai ke synthesize ʻia ʻo NAD +. ʻO ke ala syntheto De novo, ke ala Preiss Handler, a me ke ala Salvage.  

ʻO ke ala Salvage ke kaʻina maʻamau e hana ʻia ai ʻo NAD + i loko o ke kino. I kēia ala, hele ʻo NAD + i nā hopena redox. Hoʻohui ʻia e hoʻoliʻiliʻi ʻia e nā mea like ʻelua electron, a laila lilo i ʻano i kapa ʻia ʻo nicotinamide adenine dinucleotide (NADH). Ma muli o ka lawa ʻole o ka hoʻopili papaʻai no ka pono o ke kino no NAD +, hoʻohana a hoʻohana hou ke ala hoʻōla i ka NAD + i loaʻa a me nā ʻano like ʻole. 

 ʻO kekahi o nā hana nui a NAD + e hana nei e hoʻoulu nei i nā sirtuins, kahi hui o 7 mau enzyme, Sirt1 a i Sirt7. ʻO kēia mau enzyme ka hana o ke kaohi ʻana i ka ʻelemakule a me ka lōʻihi o nā hunaola. Hana nā Sirtuins i nā hana metabolic he nui, e like me ka hoʻokuʻu ʻana o ka insulin, mobilization o lipids, a me ka pane o ke koʻikoʻi. Hiki iā ia ke hoʻoponopono i ke ola. Hoʻokumu ʻia ʻo Sirtuins ke piʻi aʻe nā pae NAD +. 

ʻO NAD + kahi substrate hoʻi no kahi hui o nā protein i kapa ʻia poly ADP-ribose polymerase (PARP). ʻO ia ke kuleana no ka hoʻomaikaʻi ʻana o DNA a me ke kūpaʻa o nā genome a he kuleana paha ia no ka lōʻihi o ke ola. 

Ua emi nā pae o NAD + me nā makahiki a me nā maʻi. ʻO kekahi o nā kumu o kona emi ʻana he mumū mau, hoʻonui i ka hoʻoulu ʻana o ka ʻōnaehana pale, a hoʻemi i ka hana nicotinamide phosphoribosyltransferase (NAMPT), e alakaʻi ana i ka hoʻemi o ka hana. Ke mau nei ke kino o ke kanaka, hoʻonui ka nui o ka hōʻino ʻana o DNA me nā manawa liʻiliʻi o ka hoʻoponopono ʻana, e hōʻiliʻili ana i ka ʻelemakule a me ka maʻi ʻaʻai. 

Aia kekahi mau ala e hoʻonui ai i nā pae o NAD + pae i ke kino. ʻAi liʻiliʻi lākou i ka ʻai a me ka kaohi ʻana i ka helu o nā calorie, ka hoʻokē ʻai ʻana, a me ka hoʻoikaika kino. Hiki i kēia mau hana ke kōkua i ka mālama ʻana i ke kino a me ka hana.

ʻO nā ʻenehana ʻē aʻe e hoʻonui i ka NAD + me ka ʻai ʻana i ka tryptophan a me ka niacin a me ka lawe ʻana i nā mea hoʻoikaika ʻo NAD + e like me ka nicotinamide riboside chloride a me ka monotucleamide nicotinamide. 

ʻO Nicotinamide riboside chloride ka mea mua e hiki ai ke hoʻonui i nā pae o ke kelepona o NAD +. He kumu ia no ka Vitamin B3. He huahana ia e hana ana ma ke ala hoʻōla o ka hana NAD +. Hoʻololi ia i mononucleotide nikotinamide (NMN) me ke kōkua o ka ʻenemene NR kinase Nrk1. Hoʻohuli hou ia i NAD +. 

Ma hope o ka hāʻawi ʻana iā NR, hoʻonui nā pae o NAD + i ke kino, a laila hāʻawi ʻia i nā ʻāpana like ʻole. ʻAʻole hiki iā ia ke hele i ka pale o ka lolo-koko, akā hoʻololi ʻia i nicotinamide a laila lawe ʻia i ka lolo a me nā mea ʻē aʻe kahi e hana ai iā NAD +. 

ʻO ka hapa nui o ka ʻike e pili ana i ka pono o Nicotinamide Riboside chloride mai ka noiʻi holoholona. Kaupalena ʻia ka noiʻi ʻike kanaka a makemake nui ʻia.

 

Nā pono o ka Nicotinamide Riboside Chloride

Nui a hewahewa nā pono o ka hoʻohana ʻana iā Nicotinamide Riboside Chloride. O lākou: 

 

Ka hopena ma nā maʻi Neuromuscular

Hiki i ka Nicotinamide riboside chloride ke hoʻonui i ka NAD + hiki ke hoʻomaikaʻi i nā hana o ka mitochondria. Hiki i kēia ke kōkua i ka mālama ʻana i nā myopathies mitochondrial [1]. Hōʻike ʻia ka maikaʻi o ka pauma NR i ka hoʻomaikaʻi ʻana i nā hana o nā mustrular dystrophies.

 

Nā hopena i nā maʻi puʻuwai

Hiki i nā pilikia me ka NAD + metabolism ke hana i nā pilikia me ka puʻuwai a me nā kīʻaha koko. Hiki iā ia ke kumu i nā kūlana e like me ka puʻuwai puʻuwai, kaomi nui, myocardial infarction, etc. NR supplementation hiki ke lawe i ka lakio o NAD + a me ka nicotinamide adenine dinucleotide + hydrogen (NADH) i ka maʻamau a kū i ka hoʻololi hou ʻole ʻana o nā puʻuwai puʻuwai [2]. Hiki iā ia ke hoʻohuli i nā hopena o ka hopena o ka puʻuwai. 

 

Nā hopena ma nā maʻi neurodegenerative

Hana pinepine nā maʻi Neododegenerative me ka ʻelemakule. Pili lākou me ke koʻikoʻi oxidative i hiki ke hōʻino i ka DNA. ʻO ka maʻamau, e hana ʻia nā hana ʻē aʻe o ka mitochondria, e pili ana i kekahi mau kumu ma hope o ka hiki ʻole o nā pūnaewele ke hana maikaʻi. Hoʻemi ka NAD + i ka nui e like me ke kino o ke kino, e alakaʻi ana i ka hana kūpono ʻole o ka mitochondria. Hiki i kēia ke kumu i nā maʻi neurodegenerative like ʻole. Hiki iā ia ke hoʻonui i nā manawa o ka maʻi Alzheimer. 

Hoʻonui ka Nicotinamide Riboside chloride i ka nui o NAD + i loko o ke kino, hoʻoliʻiliʻi i ke koʻikoʻi oxidative, a hiki nō hoʻi ke hoʻoponopono i ka DNA ʻino. He mea kōkua nō hoʻi i ka mālama ʻana i ka maʻi ʻo Alzheimer i nāʻiole [3]. Hiki iā ia ke hoʻoliʻiliʻi i ka mumū i ka lolo, e kōkua ana i ka hoʻomaikaʻi ʻana i ka ʻike a me ka hoʻomanaʻo [4]. Hiki iā ia ke hana i kēia ma ka hōʻemi ʻana i ka nui o ka protein protein amyloid-β a me ka pāpā ʻana i ka amyloidogenesis. 

Hiki i ka NR pauka ke hoʻopau i ka hoʻohaʻahaʻa o nā axons i nā manawa mau o nā maʻi neurodegenerative e ka hoʻololi ʻana i ka metabolism o NR i ka axon [5]. ʻO ka hoʻohaʻahaʻa o nā neon neolal o ka ʻalalā i loko o nā koloka lauoho cochlear hiki ke hana ma hope o ka hōʻike ʻana i nā leo nui. Ua hōʻike ʻo NR he mea maikaʻi i ka pale ʻana i ka nalo ʻana o ka lohe ma loko o ka walaʻau. Hana ia i kēia ma ka hana ʻana i ka sirtuin a i ʻole ka SIRT3-hilinaʻi i ka hana e hōʻemi i ka hoʻohaʻahaʻa neurite [6].  

 

Ka hopena ma diabetics

Ua hōʻike ʻo Nicotinamide ribonucleoside chloride he mea maikaʻi i ka hōʻemi ʻana i nā ʻōuli o nā maʻi metabolic e like me ka maʻi diabetes II [7]. Ua hōʻike ʻia e hoʻomaikaʻi i ke ahonui i ka glucose, hoʻoliʻiliʻi i ke kaumaha a mālama i ka hōʻino o ke ake i nāʻiole. No laila he maikaʻi paha i ka mālama ʻana i nā kānaka pū kekahi. 

 

Ka hopena i ke olakino ate

Ua hōʻike ʻia nā ʻano akepaʻa e like me ka maʻi momona nonalcoholic momona i kumu e loaʻa ai ka hemahema NAD +. No laila, kōkua paha ka hoʻopili ʻana me ka pauma NR no ka hoʻōla hou ʻana i kēia mau ʻano [8]. 

 

Ka hopena ma ka ʻelemakule 

Ua ʻike ʻia ʻo NAD + e hoʻēmi i ka ʻelemakule o nā hunaola a hoʻōla hou iā lākou. Ua ʻike ʻia nō hoʻi e hoʻomaikaʻi i nā hana o ke koʻokoʻo koʻokoʻo i kōkua pū kekahi e hōʻemi i ka ʻelemakule [9]. 

 

Ka pōmaikaʻi o Nicotinamide Riboside Chloride ma luna o nā NAD + Precursors ʻē aʻe

ʻOi aku ka maikaʻi o ka NR bioavailability a ʻoi aku ka palekana o ka hoʻohana ʻana ke hoʻohālikelike ʻia i nā mea mua. Ua hōʻike ʻia e hoʻonui i nā pae o ka NAD + hou aʻe ma ka lawe waha ʻana i nāʻiole a hāʻawi pū i ka nui o ka NAD + i nā mākala i hoʻohālikelike ʻia i nā mea mua. Hiki iā ia ke kaohi i nā pae lipid koko maikaʻi a hoʻonui i ka pae o NAD + i ka puʻuwai [10]. 

 

Nā ʻaoʻao ʻaoʻao o Nicotinamide Riboside Chloride

ʻO ka lawe ʻana i ka waha o ka nicotinamide riboside chloride i nā lāʻau haʻahaʻa he mea palekana ia. Pākuʻi ʻia paha kekahi mau hopena ʻē aʻe e like me

• 'O Nausea
• ʻO ke koko 
• Edema
• Pana
• 'Oloke
• Headaches
• Kōkua
• ʻO ka'ōpū Upset
• ʻAnoʻai
• ʻO ka wai

 

Pehea e kūʻai ai iā Nicotinamide Riboside Chloride?

Inā makemake ʻoe e kūʻai i ka pauma NR, ʻoi aku ka maikaʻi o ka hoʻopili pololei ʻana i ka hale hana mea hana ʻo Nicotinamide Riboside Chloride. Hōʻoia ia e hoʻohana ʻia nā mea ʻoi loa no ka hana ʻana, ma lalo o ka makaʻala a ka poʻe loea i ka pili e pili ana. Hana ʻia kēia huahana e pili ana i nā kulekele palekana palekana e hōʻoia i ke ʻano kiʻekiʻe o ka huahana, me ka ikaika nui, a pūʻolo pono ʻia. E like me ka makemake o ka mea hoʻohana, hiki ke hoʻonohonoho ʻia nā kauoha e kūlike me kā lākou ʻono kikoʻī. 

Ke hana ʻia ka huahana, pono e mālama ʻia i kahi anu anuanu o 0 a 4C no ka wā pōkole a -20C no ka wā lōʻihi. ʻO ia e pale iā ia mai ka hōʻino a hana ʻana paha me nā kemika ʻē aʻe i ke kaiapuni.

 

E hoʻomaopopo '

• Chi Y, Sauve AA. ʻO Nikotinamide riboside, kahi mea moʻomeheu o nā mea ʻai i nā meaʻai, he vitamin B3 me nā hopena i ke kaola metabolism a me ka neuroprotection. ʻO Ke Kulanui ʻO Curr Opin Clin Nutr Metab. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Hoʻopau ʻana. PubMed PMID: 24071780.
• ʻO Bogan KL, Brenner C. Nicotinic acid, nicotinamide, a me ka ribotine nikotinamide: kahi loiloi molekole o NAD + precursor huaora ma ka meaʻai o ke kanaka. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Hoʻopau ʻana. PubMed PMID: 18429699.
• ʻO Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ma ke ʻano he cell-intrinsic, ke alakaʻi nei i ka mea hoʻokele e hoʻolalepa ai ka momona: kemika a me ka loiloi metabolic o nā hoʻololi acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Hoʻopau ʻana. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
• ʻO nā mea āpau e pono ai ʻoe e ʻike e pili ana iā Nicotinamide Riboside Chloride