NR pauka (23111-00-4)

April 7, 2020

ʻO Nikotinamide riboside, ʻike ʻia ʻo NR a me SRT647, he ʻano pyridine-nucleoside o ka vitamini B3 e hana ana ma ka mua o ka nicotinamide adenine dinucleotide a i ʻole NAD +. NR poloka degeneration o beast dorsal root ganglion neurons ex vivo a pale aku me ka pale ʻana i ka lohe ʻole i nā kani leo e pili ana i nā kiʻina ola.

 


Kūlana: I ka Production Production
Mokuna: 1kg / ʻeke, 25kg / Drum

 

NR pauka (23111-00-4) wikiō

 

Nikotinamide Riboside Chloride (NR) Snāʻike

Name: ʻO Nicotinamide Riboside Chloride (NR)
CAS: 23111-00-4
Purity 98%
Kaulike Molecular: C11H15ClN2O5
Kaumaha Molecular: 290.7 g / mol
Wahi Manaʻo: 115-125 ℃
Inoa inoa inoa inoa: 3-carbamoyl-1-((3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium chloride
Hōʻuluʻulu Manaʻo: Nicotinamide riboside; SRT647; SRT-647; SRT 647; Nicotinamide Riboside Triflate, ʻĀina / β hui
InChI Key: YABIFCKURFRPPO-FSDYPCQHSA-N
Half Ola: 2.7 hola
Palekana: Hoʻopau maikaʻiʻia i DMSO, Methanol, Wai
Ke kūlana Mana: 0 - 4 C no ka wā pōkole (mau lā a i mau pule), a i ʻole -20 C no ka wā lōʻihi (mahina)
noi: Ua hoʻopiʻi ʻia ʻo Nikotinamide riboside he ʻano hou pyridine-nucleoside o ka vitamin B₃ e hana ana ma ke ʻano o ka nicotinamide adenine dinucleotide a i ʻole NAD +.
ʻAno: Holo ke keʻokeʻo a ʻike i ka pauka Pale ʻula

 

He aha ka Nicotinamide Riboside Chloride paukū CAS 23111-00-4?

ʻO ka riboside Nicotinamide, i ʻike ʻia ʻo NR a me SRT647, he ʻano pyridine-nucleoside o ka vitamini B3 e hana ana ma ke ʻano o ka hana loea ma nicotinamide adenine dinucleotide a i ʻole NAD +. NR poloka degeneration o beast dorsal root ganglion neurons ex vivo a pale aku me ka pale ʻana i ka lohe ʻole i nā kani leo e pili ana i nā kiʻina ola. Hoʻopili ʻo Nicotinamide riboside i ka ʻiʻo, neural a me melanocyte stem cell senescence. ʻO ka hoʻonui ʻia ʻana o ka mau mākala me nā isika ua mālama ʻia ma hope o ka mālama ʻana me ka nicotinamide riboside, e alakaʻi ana i ka manaʻo e hiki ai ke hoʻomaikaʻi hou i nā hanana hou e like me ka palaka, aʻae, a me nā puʻuwai. ʻO Nicotinamide riboside e hoʻohaʻahaʻa ana i ka hoʻokahe koko a me nā momona momona i ka prediabetic a me nā hoʻohālikelike 2 ʻano maʻamau no ka pale ʻana i ka hoʻomohala ʻana o ka maʻi peripheral diabetes. Nānā: ʻO Nikotinamide Riboside chloride he pākuʻi α / β.

 

 

ʻO Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 mau pōmaikaʻi

ʻO nā nucleosides Nicotinamide he mea kūpono o ka nicotinamide adenine dinucleotide (NAD) a i hōʻike i kahi kumu o ka vitamin B3. Ua hōʻike ʻia nā noiʻi hou ʻana i ka lawe ʻana i ka nui o nā nukleine ʻo Nikotinamide kūlohelohe maoli i loko o nā meaʻai e hiki ke hāʻawi i nā pono olakino hou. No ka hoʻohālikelike, ua hoʻokomo ʻia nā nukleinamide nicotinamide i ka hoʻonui ʻana i ka hoʻolālā NAD kiko a me ka hoʻomoe ʻana i ka naʻau o ka insulin a me ka hoʻomaikaʻi ʻana i ka hana sirtuin. ʻO kona hiki i ka hoʻonui ʻana i ka hana NAD e kuhikuhi ana i ka nucleotides nicotinamide hiki ke hoʻomaikaʻi i ke olakino mitochondrial, hōʻeuʻeu i ka hana mitochondrial, a koi aku i ka hana o nā mitochondria hou. ʻO nā haʻawina ʻē aʻe me ka hoʻohana ʻana i nā nucleotides nicotinamide i loko o ka maʻi maʻi Alzheimer ua hōʻike ʻia ka bioavailable i ka lolo a hāʻawi i ka neuroprotection ma ka hoʻoulu ʻana i ka lolo NAD synthesis.

Hiki iā Nicotinamide Riboside Chloride ke hōʻemi i ke kaupaona: Ua hōʻike ʻia nā noiʻi ʻana e ka hoʻonui ʻana i ka ikehu metabolism, hiki iā ʻoe ke hōʻemi pono i ka papaʻai momona momona i hoʻoulu ʻia i ke kaumaha. I mea e loiloi ai i ka ʻōnaehana ribot nikotinamide o ka NR e paipai ana i ka pohō kaumaha, ana nā mea noiʻi i ka hana mitochondrial o ke ake e pili ana i ka ʻai pūnao, ka hana, nā calorie, ke anai o ka pūhaka, ka helu metabolic hoʻomaha, ka haku ʻana o ke kino, ka hoʻomanawanui ʻana o ka glucose, ka ʻike insulin a me nā ʻano biochemical a me metabolomics nā palena ʻO kēia mau ʻikepili a me ke ʻano hoʻohaʻahaʻa kaumaha hou e ka malabsorption, excretion o nā meaola biology no ka huli ʻana. Ua hōʻike nā kānaka noiʻi ua hānai nā ʻiole i nā nikotinamide nikotinamide i mea e nui ai ke kaupaona e pili ana i nā ʻiole ʻaʻole i hoʻopihapiha i ka nicotinamide.

 

 

ʻO Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 Hoʻolaha i ka hana?

ʻO Nicotinamide Riboside Chloride (NR) nā nucleosides i mua o ka nicotinamide adenine dinucleotide (NAD) a hōʻike i kahi kumu o ka huaʻai B3. Ua hōʻike ʻia nā noiʻi ʻana i ka lawe ʻana i kahi nui o nā nicotinamide nucleosides kūlohelohe i loko o nā meaʻai hiki ke hāʻawi i nā pono olakino hou. ʻO kahi laʻana, ua hoʻopili ʻia nā nicotinamide nucleosides i ka hoʻonui ʻana i ka nui o ka NAD a me ka hoʻoulu ʻana i ka ʻike insulin a me ka hoʻomaikaʻi ʻana i ka hana sirtuin. Hōʻike kona hiki ke hoʻonui i ka hana NAD i hiki i nā nicotinamide nucleosides ke hoʻomaikaʻi i ke olakino mitochondrial, hoʻoulu i ka hana mitochondrial, a hoʻoulu i ka hana ʻana o mitochondria hou. ʻO nā noiʻi ʻē aʻe e hoʻohana ana i nā nicotinamide nucleosides i ke ʻano maʻi o Alzheimer ua hōʻike ʻia e hiki ke mālama ʻia ka mole i ka lolo a hāʻawi paha i ka neuroprotection e ka hoʻoulu ʻana i ka lolo NAD synthes ..

 

 

ʻO Nicotinamide Riboside Chloride (NR) CAS 23111-00-4 noi

Ua hōʻike ʻia nā haʻawina mua a ʻo ka hoʻohui ʻana o ka ribotine nicotinamide ʻaʻole hiki ke hoʻonui wale i nā pae NAD + me ka maluhia, akā hiki nō hoʻi i ke hoʻonui ʻana i ka hoʻohana ʻana o NAD + i nā kānaka, ʻaʻole hiki ke loaʻa kekahi mau huahelu B3.Studies i hōʻike ʻia i ka manawa o ka ribotinamide ka puka i loko o ka pūlima, hoʻololi koke ke kino iā NAD +. ʻO kēia NAD + laila hoʻoulu i ke kaʻina o ka hoʻomakaʻina intacellular i ka hoʻokumu ʻana i ka ikehu ma mitochondria

Hiki i ka Nicotinamide Riboside Chloride ke hoʻonui i ka hana mitochondrial, ka mea i hōʻike ʻia e hoʻoikaika ai i ka hōʻike o nā protein chain mitochondrial protein, hoʻonui i ka hiki ke mitochondrial membrane maʻa, a hoʻonui i ka helu o ka hanu o ka oxidative a me nā pae ATP intracellular. Hiki ke mālama pū ʻia e nā kiʻekiʻe kiʻekiʻe o ka mitochondrial regeneration. Hoʻololi ka hana Mitochondrial i ko mākou wā e ulu nei, a ʻo ia ka hōʻailona o ka wā o nā ʻōhua ololi e loaʻa nei iā mākou. Hiki i ka NR ke hoʻonui i ka hana o ka mitochondria a hoʻokaʻawale i ka senescence o nā cell stem.

 

NR ka lehu no ka kuai(Ma ke kūʻai aku i ka pulupulu Nicotinamide Riboside Chloride (NR) paukū

ʻOliʻoli kā mākou ʻoihana i nā pilina lōʻihi e ko mākou mea kūʻai aku no ka mea ke nānā aku nei mākou i ka lawelawe o ka mea kūʻai aku a hāʻawi i nā huahana maikaʻi. Inā makemake ʻoe i kā mākou huahana, maʻalahi mākou me ka hoʻokaʻawale ʻana i nā kauoha e kūpono i kāu pono kūikawā a me ko mākou wikiwiki wikiwiki i nā kauoha e hōʻoia ʻoe e hoʻāʻo nui i kā mākou huahana i ka manawa. Hoʻomaopopo pū mākou i nā lawelawe i hoʻohui ʻia. Loaʻa mākou i nā nīnau a me ka ʻike e kākoʻo i kāu ʻoihana.

 

He lāʻau loea ʻo mākou ʻo Nikotinamide Riboside Chloride (NR) i mau makahiki he nui, hoʻolako mākou i nā huahana me ke kumu kūʻai, a ʻo kā mākou huahana o ke ʻano kiʻekiʻe loa a ma lalo o ka hoʻomaʻamaʻa kūʻokoʻa, kūʻokoʻa kūʻokoʻa e hōʻoia ai ka palekana no ka hoʻohana ʻana ma ka honua.

 

E hoʻomaopopo '

  • Chi Y, Sauve AA. ʻO Nikotinamide riboside, kahi mea moʻomeheu o nā mea ʻai i nā meaʻai, he vitamin B3 me nā hopena i ke kaola metabolism a me ka neuroprotection. ʻO Ke Kulanui ʻO Curr Opin Clin Nutr Metab. 2013 Nov; 16 (6): 657-61. doi: 10.1097 / MCO.0b013e32836510c0. Hoʻopau ʻana. PubMed PMID: 24071780.
  • ʻO Bogan KL, Brenner C. Nicotinic acid, nicotinamide, a me ka ribotine nikotinamide: kahi loiloi molekole o NAD + precursor huaora ma ka meaʻai o ke kanaka. Annu Rev Nutr. 2008; 28: 115-30. doi: 10.1146 / annurev.nutr.28.061807.155443. Hoʻopau ʻana. PubMed PMID: 18429699.
  • ʻO Ghanta S, Grossmann RE, Brenner C. Mitochondrial protein acetylation ma ke ʻano he cell-intrinsic, ke alakaʻi nei i ka mea hoʻokele e hoʻolalepa ai ka momona: kemika a me ka loiloi metabolic o nā hoʻololi acetyl-lysine. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48 (6): 561-74. doi: 10.3109 / 10409238.2013.838204. Hoʻopau ʻana. PubMed PMID: 24050258; PubMed Central PMCID: PMC4113336.
  • ʻO nā mea āpau e pono ai ʻoe e ʻike e pili ana iā Nicotinamide Riboside Chloride