No ke aha e pono ai mākou iā Nikotinamide Riboside Chloride

ʻO ka ʻoihana ʻenehana he pāneka bililiona, ma mua nui no ka nānā ʻana o ke kanaka kanaka me ke ʻano o ko lākou nānā ʻana. ʻO kēia hoʻi ka kumu nui a ke kumu i noiʻi ai a puni nā huahana anti-kahiko a ʻo nā huahana i hoʻoikaika ʻia i mua o kahi manawa pōkole loa. Hoʻomaopopo nā poʻe kūkā honua āpau ua loaʻa ke kālā e hana mai nā makemake o nā kānaka e noho mau a mau a ʻōpiopio a pēlā nō, aia nā hui i ka wahi, ka hoʻolilo ʻana i nā lā a me nā hebedoma e ʻike i nā huahana a me nā huahana e hiki ai ke hoʻonui i ke ʻano kino. Ua loaʻa iā Nicotinamide Riboside a ʻo Niagen ma muli o kēia ʻimi ʻole ʻole ʻia no nā huahana anti-kahiko. ʻOiai ka hapanui o nā huahana anti-kahiko e hōʻemi i nā hōʻailona o ka hele ʻana mai ka ʻili, hoʻēmi ʻo Niagen i nā hōʻailona o ka hele ʻana i loko o ke kino. ʻO Nikotinamide Riboside a ʻo Niagen ka ʻano kristal o ʻO Chotide ʻO Nikotinamide a i ka manawa hoʻokahi i loko o ke kino, e hoʻohuli iā ia i NAD +, nona ke kuleana maikaʻi a me nā ʻano ʻē aʻe ʻē aʻe.

Ma kēiaʻatikala, uhi mākou i nā mea āpau o kēia pūnaehana kahaha, me kāna mau pōmaikaʻi, nā ʻaoʻao a me nā ʻano kūpono.

He aha ia ʻo Nicotinamide Riboside Chloride?

ʻO Nicotinamide Riboside Chloride a ʻo Niagen ka ʻano kristal o Nicotinamide Riboside, he vitamin a NAD + precursor. Eia ke paona ʻo Nicotinamide Riboside he 255.25 g / mol, ʻo Nikotinamide Riboside Chloride ke kaupaona 290.70 g / mol a me 100 mg o Nicotinamide Riboside Chloride e hāʻawi ana i ka 88 mg o Nicotinamide Riboside. Manaʻo ʻia ʻo NR i palekana e hoʻohana i nā meaʻai.

ʻOiai ʻo Nikotinamide Riboside ke ʻano o Vitamin B3, ʻo kona mau ʻāpana like ʻole e ʻokoʻa pono mai nā mea he nui o nā lālā ʻē aʻe o ka hui B3, e like me ka nicotinamide a me ka niacin. ʻOiai ʻo Niacin e hoʻoheleheʻe i ka ʻili ma ka hoʻōla ʻana i ka GPR109A G-protein i hoʻohui ʻia, ka hopena ʻo Nicotinamide Riboside i kēia mea a me kēia mea i hāʻawi ʻia, no laila ʻaʻole ia e hoʻonāukiuki i ka ʻili, ʻoiai e pau i ka nui o ka nui o ka 2000 mg i kēlā me kēia lā. Eia kekahi, nā hoʻokolohua i hana ʻia i nā kiʻī i hōʻike ʻia ʻo Nicotinamide Riboside ka mea nāna ʻo NAD + i alakaʻi i kahi kiʻekiʻe loa i Nicotinamide Adenine Dinucleotide a me NAD + i loko o ke kino.

ʻO ka Nicotinamide Riboside e hele maoli i kaʻai o ke kanaka a hoʻokahi i loko o ke kino, e loli ana iā NAD +, e pono ai ke kino no nā hana like ʻole. No ka mea, ua hōʻike ka noiʻi ʻepekema ʻo Nicotinamide Riboside Chloride a me NAD + hoʻolako ʻia e NR hoʻomaikaʻi i ka hana mitochondrial a me ka hoʻohaʻahaʻa ʻana i ka insulin i ka hoʻoulu ʻia ʻana o ka ʻohana sirtuin o nā enzymes, ka mea pili i ka hoʻoponopono ʻana i ka metabolid ka oxidative i loko o ke kino.

I kēia manawa, ua ʻelima mau noi i hoʻopaʻa ʻia e hoʻopaʻa i ka palekana a me ka hoʻopōmaikaʻi o Nicotinamide Riboside a me kēia mau ʻike āpau ua ʻike i kēia mea hoʻopukapuka e palekana ai no ka hoʻohana kanaka.

ʻO Chotide ʻO Nikotinamide maika

Ma mua o mākou e kamaʻilio i ka Nā pōmaikaʻi o Nicotinamide Riboside Chloride, he mea pono e hoʻomaikaʻi, no ka mea, ʻo Nicotinamide Riboside Chloride ka paʻakai kahi i loaʻa ai ʻo Nicotinamide Riboside, nā pōmaikaʻi o Nicotinamide Riboside Chloride e like me nā pōmaikaʻi o Nicotinamide Riboside.

●Ua hoʻolaha ʻo Nicotinamide Riboside Chloride i kahi olakino olakino

Hana ʻia ka NAD + e Nicotinamide Riboside Chloride i loko o ke kino e hoʻopili i nā enzyme kikoʻī e pili ana me ka ʻoluʻolu olakino. ʻO kekahi ʻano like o nā sirtuins, kahi i pili me ke ola maikaʻi a me ka ola o nā holoholona. Ua hōʻike ʻia nā noiʻepekema ʻepekema e hoʻomaikaʻi ka sirtuins i ke ola o ka ola a me ka lōʻihi ma o ka hoʻemi ʻana i ka hana palupalu, hoʻonui i nā pono e pili ana i ka hoʻopalike kalala a me ka hoʻoponopono ʻana i ka DNA i hoʻopau ʻia. Nā NAD + i hoʻoneʻe ʻia e Nicotinamide Riboside Chloride e hooulu ana i ka poly polymerases i ʻike ʻia e hoʻoponopono hou ʻia i ka DNA nāwaliwali. Eia kekahi, nui nā noiʻi ʻepekema i hoʻopili i ka hana o nā polymerases me ka lōʻihi o ke ola.

●E hōʻemi ana i kekahi pono o ke kūkuluʻana i nā maʻi naʻau

Hoʻonui ka ʻōpū i kahi manawa i ka ulu ʻana i nā maʻi naʻau. Ke hele nei ka poʻe i ka wā ʻelemakule, ʻoi aku ka nui o kā lākou koko koko me ka ikaika, ʻo ia hoʻi, e alakaʻi i ka nui o ke koko. Ke piʻi ka nui o ke koko i loko o nā moku, pono e hana pālua ka naʻau e hoʻomoʻi i ke koko, e alakaʻi ana i nā ʻano maʻi like ʻole. ʻO ka NAD + i hāʻawi ʻia e Nicotinamide Riboside Chloride e hoʻohuli i nā loli i pili i ka makahiki i kumu i nā kīʻaha koko. He nui mau hōʻikeʻike ʻepekema e hōʻoia i ka Nicotinamide Adenine Dinucleotide a i ʻole NAD + ʻaʻole ia e hōʻemi i ka hoʻopaʻi koko, akā e hoʻoponopono pū i ke kaomi koko systolic.

●ʻO Nicotinamide Riboside Chloride Ka hāʻawi pū ʻana i ka pale i nā pūnaʻi ʻoi nāu

Mālama ʻo Nicotinamide Riboside i nā kuleana olakino. Ua hōʻike ʻia kahi hōʻike ma nā kiʻikuhi i ka hana o NR-hoʻoneʻe i ka NAD + i hoʻonui i ka hana o ka protein PGC-1 alpha a hiki i 50%. Mālama ka protein alpha PGC-1 i ka pale o nā lolo i ke koʻikoʻi o ka oxidative stress a hoʻomaikaʻi hou i ka hana mitochondrial. A eia nō naʻe, ʻo ka mālama ʻana o NR i nā kānaka e pale aku i nā maʻi o ka lolo, ua like me nā Alzheimer a me Parkinson. Ua aʻo ʻia kekahi noiʻi noiʻi noiʻi i ka hopena o nā pae o NAD + i nā poʻe e loaʻa ana ka maʻi o Parkinson. Ua hoʻopaʻa ʻia ka noiʻi ʻana ʻo ka pono o NAD + i hoʻomaikaʻi i ka mitochondrial function i loko o nā koena.

Nā pono ʻē aʻe o Nicotinamide Riboside Chloride

ʻOi aʻe o nā pono i ʻōlelo ʻia ma luna, eia kekahi mau pōmaikaʻi hou e pili pū ana me ka Nicotinamide Riboside Chloride.

  • ʻIke ʻia ka NR e hoʻoikaika i ka ikaika o ka ʻiʻo, hana a me ka hoʻomanawanui a no laila, ua hoʻopili ʻia ka make o NR me ka hoʻokūkū pili maikaʻi.
  • E like me ka mea i kūkākūkā ʻia ma luna, hana neʻe NR-hoʻoneʻe i ka NAD + hoʻoponopono i ka DNA hōʻino a hāʻawi i ka pale i ke koʻikoʻi oxidative. ʻO kēia, ma ke ʻano he hōʻemi ʻana i kekahi manawa i ka ulu ʻana i ka maʻi maʻi.
  • Ua noiʻi ʻia kahi noiʻi i ka hopena o Nicotinamide Riboside ma ka hana hoʻokalakupua i nā isika. Ua pau ka noiʻi ʻana hoʻonui ʻo NR i ka hana mika i nā kiʻina. ʻOiai e pono ai ka hōʻike ʻepekema hou aʻe e pili ana i kēia, nui nā mea ʻepekema e manaʻo nei he hopena like ʻo Nicotinamide Riboside i nā kānaka a no laila, pono ke kōkua me ka hoʻolilo kaumaha.

ʻO Chotide ʻO Nikotinamide

ʻO ka Dosage o Chotide ʻo Nicotinamide

ʻO nā haʻawina ʻelima e hana nei a hiki i kēia manawa ua hoʻokūpaʻa ʻo ia ʻo Nicotinamide Riboside e palekana no ka hoʻohana kanaka. Akā, ua hoʻokūpaʻa kēia mau noiʻi i ka palekana ʻO Chotide ʻO Nikotinamide ʻike kaupalena kanaka no waena o 1,000 a 2,000 mg i ka lā. Eia nō naʻe, pono e mālama i nā haʻawina a pau i hoʻopaʻa ʻia i ka palekana o Nicotinamide Riboside he liʻiliʻi ʻāpana liʻiliʻi a no laila, ʻoi aku ka noiʻi o ka noiʻi ma kēia wahi.

ʻO ka kumu nui o ka Nicotinamide Riboside Chloride e hāʻawi pono iā Nicotinamide Riboside Chloride a i Niagen i ke kino. Loaʻa ka Niagen a i ʻole NR i nā ʻano ʻelua: nā papa a me nā ʻopi. Nui nā loina Nicotinamide Riboside hui pū me NR me nā kumuhana ʻē aʻe, e like me Pterostilbene. Ma kekahi kī, e palekana, ʻo ka hapa nui o nā mea hana hoʻopihapiha e mālama i ka mālama ʻana i ka lā maʻamau o NR ma waena o 250 i 300 mg i kēlā me kēia lā.

Noho palekana ʻo Nikotinamide Riboside Chloride?

ʻO nā mau noiʻi i hana ʻia a hiki i kēia manawa i loaʻa ai ka make ʻana o Nicotinamide Riboside ma ka kahele o 1000 a 2000 ka lā i ka palekana no ka hoʻohana kanaka. Eia naʻe, ʻoiai e pono ai nā noiʻi paʻa aku i kēia wahi, kākuhi ʻo Nicotinamide Riboside i ka mālama ʻana i kekahi lā o kā NR ma lalo o 250-300 mg i kēlā me kēia lā.

ʻOiai ka palekana ʻānai a Nicotinamide Riboside a ʻo Nicotinamide Riboside Chloride, hiki iā ia ke alakaʻi i nā ʻaoʻao like ke ʻano o ka nausea, ka ʻiwi, ka indigestion, nā ʻeha a me nā ʻeha. Inā ʻike ʻoe i kekahi o kēia mau hōʻailona i ka wā e lawe nei i kahi kākoʻo NR, e kamaʻilio koke i kāu kauka. Eia kekahi, no ka mea ʻaʻole lawa nā hōʻike e pili ana i ka hopena o Nicotinamide Riboside ma nā wahine hāpai a me nā hūmū waiū, pono e haʻalele kēia pūʻulu mai ka hoʻohana ʻana o nā mea hoʻohui a Nicotinamide Riboside.

ʻO Chotide ʻO Nikotinamide kumukanawai a

Inā ʻoe e ʻimi i kahi mea iʻa ʻO Chotide ʻO Nikotinamide hoʻoponopono hou, hōʻike mākou i ka hoʻohui Tru Niagen Nicotinamide Riboside. Hoʻohana kēia kumukanawai iā NIAGEN, ka huahana NR i hoʻopaʻa ʻia nā huahana. E hui pū ka ʻoihana hana hana me ka hoʻopiha ʻia ʻana o Nicotinamide Riboside a no laila, hiki i kekahi ke hilinaʻi i ka ʻoi aku ua maikaʻi loa nā lako hoʻohui. Ma o ka Tru Niagen Nicotinamide Riboside ka hele mai i loko o nā pahu pīpī maʻalahi, ke maʻalahi no ka maʻalahi. Pono nā mea hoʻohana e lawe i hoʻokahi kapsul i hoʻokahi lā.

Eia nō naʻe, inā e ʻimi ʻoe i kahi gluten, hua manu, BPA, nati, nā pelekikena a me ka huahana ʻole-dairy-product, hoʻolaha mākou i ke kau ʻana i kāu kālā ma ka Thorne ResveraCel Nicotinamide Riboside supplement. Hoʻopili kēia hoʻohui i ka NR me nā flavonoids. Hoʻopili, ʻelua mau mea e hoʻomaikaʻi i ka hana sirtuin. ʻOi aku ka mea nui, koi ʻo Thorne ResveraCel e hana ʻehā mau hoʻāʻo e hoʻohālikelike i kēlā me kēia o kāna lako, a pēlā pū me ka palekana o ka hui. Eia kekahi, ua hoʻolako ʻia kēia mau lako i kahi palapala i hōʻoia ʻia e cGMP i ʻAmelika Hui Pū ʻIa a i kahi TGA i hōʻoia ʻia ma Ausetalia.

ʻO Chotide ʻO Nikotinamide

Kahi e kūʻai ai ʻO Chotide ʻO Nikotinamide Pau loa i ka Hanu?

Ua hoʻonui nui ʻia ka noi no nā lako hou o Nicotinamide Riboside i nā makahiki i hala iho nei, no ka mea he nui nā pono o Nicotinamide Riboside. Inā ke nānā nei ʻoe i ka hūnā i ka mākeke hoʻouluulu ʻo Nicotinamide Riboside, ʻo ka mea mua āu e hana ai, ʻo ia ke ʻike i kāu mea hoʻomohala kūpono a hilinaʻi hoʻi ʻo ia. I kahi kuai ʻO Chotide ʻO Nikotinamide pauku ma ka ʻōpala? Ala akula ka p? Na ka pane ʻO Cofttek.

ʻO Cofttek kahi mea lako kai hana i hiki mai i ka makahiki 2008 a i ka hapa wale nō o hoʻokahi haneli, ua hoʻokumu ka hui i kona hele ʻana i kekahi mau ʻāina. ʻOi aʻe ma mua o ka hana ʻana i nā huahana pono, e hoʻopili pū ana ka ʻoihana ma ka hana ʻana i ka holomua o ka ʻoihana biotechnology, ka ʻenehana a me nā hoʻokolohua lāʻau. Ke kūpaʻa nei hoʻi ka ʻoihana i ka noiʻi maikaʻi, e hāʻawi iā ia i kahi pale ma luna o nā mea hoʻouka ʻē aʻe i ka mākeke. O ka ʻO ka pauku Nicotinamide Riboside Chloride hoʻolako ʻia e ka ʻoihana e hele i nā ʻeke o 25 kg a hiki ke hilinaʻi ʻia no ka maikaʻi. Eia hou, he maikaʻi loa ka ʻoihana a me ka hui kākoʻo o ka mea kūʻai aku e mālama i kāu pono a me kāu nīnau i ka manawa maoli. ʻO kēia, inā makemake ʻoe e kūʻai i ka pauma Nicotinamide Riboside Chloride ma ka nui, e hilinaʻi wale iā Cofttek.

E hoʻomaopopo '
  1. Conze, D., Brenner, C. & Kruger, Cl Safety a me Metabolism o ka hoʻokō ʻana i ka wā lōʻihi o NIAGEN (Nicotinamide Riboside Chloride) i kahi Lula Hoʻonalua, Mālama Pelekikena, Hoʻolaha Placebo e alakaʻi ai i ka maʻi pākeke. Hoʻoponopono Sci9, 9772 (2019)
  2. Carlijn ME Remie, Kay HM Roumans, Michiel PB Moonen, Niels J Connell, Bas Havekes, Julian Mevenkamp, ​​Lucas Lindeboom, Vera HW de Wit, Tineke van de Weijer, Suzanne ABM Aarts, Esther Lutgens, Bauke V Schomakers, Hyung L Elfrink, Rubén Zapata-Pérez, Riekelt H Houtkooper, Johan Auwerx, Joris Hoeks, Vera B Schrauwen-Hinderling, Esther Phielix, Patrick Schrauwen, Nicotinamide riboside supplementation alters body body and skeletal muscle acetylcarnitine concentrations in health obese people, ʻO ka American Journal of Clinical Nutrition, Volume 112, Kauoha 2, ʻAukake 2020, ʻApana 413–426
  3. Elhassan, YS, Kluckova, K., Fletcher, RS, Schmidt, MS, Garten, A., Doig, CL, Cartwright, DM, Oakey, L., Burley, CV, Jenkinson, N., Wilson, M., Lucas , S., Akerman, I., Seabright, A., Lai, YC, Tennant, DA, Nightingale, P., Wallis, GA, Manolopoulos, KN, Brenner, C., ... Lavery, GG (2019). ʻO Nicotinamide Riboside e hoʻohui i ka ʻĀpana Palani Hoʻo Heʻenehana NAD + Metabolome a me Induces Transcriptomic a me nā hōʻailona Anti-inflammatory. Nā hōʻike Pūnaewele, 28(7), 1717–1728.e6.
  4. ʻO ka pauku Nicotinamide Riboside Chloride

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