MAKUAHI HUAKAI MAKUAHI

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ʻO ka metabolism kino maʻamau
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Pau kaʻino
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ʻO ka radiation o Ultraviolet
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Ka hoʻohaumia kaumaha
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Hoʻohauna pesticide
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Hoʻohauna pesticide

KA HUAKAI MA NĀ MAU LOA

ʻO ka maʻamau, pono nā radical manuahi no nā kino, akā hiki i nā radical manuahi keu ke kumu i ke kaulike ʻole o ka hana physiological, a laila e alakaʻi i ke koʻikoʻi oxidative e ulu nei i nā maʻi like ʻole (hōʻike nā palapala i nā kumu radical free nā kumu o nā ʻano maʻi).

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ANTIOXIDANT

ʻAʻole hiki i ko mākou kino ke hana me ka ʻole o ka oxygen, a i ka manawa i hoʻonui ʻia ka nui o nā radical manuahi, hoʻonui ke kino ma lalo o ke koʻikoʻi oxidative i ka ʻōnaehana hoʻoponopono i ka hemo ʻana i nā radical free. I nā kūlana kūikawā, pono ke kino e hoʻopiha i nā antioxidants i ka vitro e wehe i nā radical free free.

HOU O NA ANTIOXIDANTS

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L-ERGOTHIONEINE –A ANO HOU O KE ANTIOXIDANT KūIKI

EGT he kino chiral amino-acid antioxidant biosynthesized i loko o kekahi koʻohune a me ka fungi. He hui bioactive nui ia i hoʻohana ʻia ma ke ʻano he scavenger radical, kahi kānana ray ultraviolet, kahi mea hoʻokele o nā hopena hoʻohaʻahaʻa hoʻoliʻiliʻi a me nā bioenergetics pūnaewele, a me kahi cytoprotector physiological, etc.
L-Ergothioneine (EGT, ERGO, CAS: 497-30-3), ʻike pū ʻia kekahi (S) -α-Carboxy-2,3-dihydro-N, N, N-trimethyl-2-thioxo-1H-imidazole- ʻO 4-ethanaminium paʻakai loko, i hana mua ʻia mai ergot e Tanret C i ka makahiki 1909, laila ua ʻike ʻia nō hoʻi i ke koko o nā holoholona. Eʻae keʻokeʻo keʻokeʻo ka EGT maʻa i ka wai, (hoʻoheheʻehe ʻia 0.9mol / L i ka lumi o ka lumi). ʻAʻole hiki ke hele ka Autoxidation ma ka waiwai pH physiological a i ʻole ka hopena alkaline ikaika. Hiki i ke EGT ke ola i ʻelua mau isomer - kahi thiol a me kahi ʻano thione, e like me ka hōʻike ma lalo nei.

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ANTIOXIDATION

Me nā maikaʻi o nā hana maha, EGT kū i waena o nā antioxidant ʻē aʻe.

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KEKAHI

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Me nā maikaʻi o nā hana lehulehu, kū ʻo EGT i waena o nā mea ʻē aʻe he nui antioxidantsNā mea kōkua (hoʻohālikelike ʻia me glutathione, cysteine ​​etc.):
——EGT ʻoi aku ka maʻalahi o ka hōʻiliʻili ʻana i nā pūnaewele a ʻoi aku ka paʻa o ka paʻa ma mua o nā antioxidants ʻē aʻe.
—— ʻoi aku ka maikaʻi o ka hoʻoliʻiliʻi ʻana i ka make cell i lawe ʻia e ka pyrogallol.
——EGT hūnā nui iā ROS e pale aku i ka hoʻōpō ʻana, ʻoiai ʻo glutathione a me nā mea ʻē aʻe e ʻokiʻoki i nā radical free, ʻo ia hoʻi, nā antioxidants nā huahana hoʻoheheʻe scavenge.

KOMO NO O KA ANTIOXIDAI

Results: EGT ʻo ia ka scavenger hana nui o nā radical manuahi ke hoʻohālikelike ʻia i nā antioxidants maʻamau e like me GSH, uric acid a me trolox. Ma ke kiko kikoʻī, ʻo ka mana antioxidant kiʻekiʻe loa i hōʻike ʻia e EGT vs. peroxyl radicals i hopena 25% ʻoi aku ma mua o ka waiwai i loaʻa me ke kuhikuhi antioksidano trolox. ʻO ka māka scavenging o EGT i nā hydroxyl radicals he 60% kiʻekiʻe, ke hoʻohālikelike ʻia me ka acid uric, e hōʻike ana i ka antioxidant kūmole vs. ʻO ka mea hope loa, ua hōʻike ʻo EGT i ka hana antioxidant kiʻekiʻe loa i ka peroxynitrite, me ka hiki ke hoʻouluulu i 10% kiʻekiʻe ma mua o ka uric acid.

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Nā Manaʻo NUI

Loaʻa iā EGT nā hopena i ka hoʻoponopono ʻana i ka ikaika intracellular,
hoʻonui i ka pale ʻana,
ka hoʻomaikaʻi ʻana i ka helu ola ʻana o ka sperm,
ka pale ʻana i ka ate mai ka ʻeha,
hoʻohuihui ʻaila
kahaulookelea,
nā hemahema a me ka cataract.

NECESSITY O HOU

① Ua ʻike ākea ʻo EGT i nā mea kanu a me nā holoholona

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STR OLELO HOOLAHA

5-10mg no kēlā me kēia anakahi no ke kanaka makua a he mea nui ka 2-3 mau ana o ka hana mau i kāu papaʻai o kēlā me kēia lā.

Pūnaewele: Li Yiqun, Zhou Nianbo. Nā Manaʻo Biology a me nā noi o EGT [J]. Keʻena ʻOihana ʻĀpana , 2010,9 (3) : 26-28.

Ua helu ʻia nā ʻai i lalo penei:

Lāʻau (3-11 mau makahiki) ≤l 0 mg / lā
Nā ʻōpio (11-21 mau makahiki) ≤30 mg / lā
Nā pākeke (21-80 mau makahiki) ≤30 mg / lā

Kahakaha : 1. Nā hana no nā keiki a me nā mākua (3 -80 makahiki)

2. ʻAʻole pono e hoʻohana i nā wahine hāpai a i ʻole nā ​​lactating.

Pūnaewele: Tetrahedron i ke noi ʻana iā US NDI

Hōʻike ʻikepili: 10.5mg / g no ka OXIS's ADI (ʻAe ʻia i kēlā me kēia lā.

③ KAULANA

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EXTRACTION & APPLICATION

(1) NUI

I kēia manawa, ʻekolu mau hana no ka hana EGT: synthesi kemika, maoli kāʻili-bio (ʻo ka mea nui mai nā mushroom, nā meaola holoholona a me ka lawe ʻana i ke koko), a me ke ʻano biosynthesis.

Hoʻohālikelike o ka EGT Extraction Nā Papahana

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(2) noi

Loaʻa nā noi ākea a EGT i nā mea hoʻonani, nā meaʻai kūpono, nā lāʻau lapaʻau, nā mea hoʻōla, biomedicine, a pēlā aku.

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(3) NA MEA E HIKI ANA

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Contents